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赵志军, 魏文涛, 李明振, 曹静. 2013: 随机限食和重喂食对小鼠体重、能量收支及瘦素的影响. 动物学研究, 34(6): 574-581. DOI: 10.11813/j.issn.0254-5853.2013.6.0574
引用本文: 赵志军, 魏文涛, 李明振, 曹静. 2013: 随机限食和重喂食对小鼠体重、能量收支及瘦素的影响. 动物学研究, 34(6): 574-581. DOI: 10.11813/j.issn.0254-5853.2013.6.0574
Zhi-Jun ZHAO, Wen-Tao WEI, Ming-Zhen LI, Jing CAO. 2013: Body mass, energy budget and leptin of mice under stochastic food restriction and refeeding. Zoological Research, 34(6): 574-581. DOI: 10.11813/j.issn.0254-5853.2013.6.0574
Citation: Zhi-Jun ZHAO, Wen-Tao WEI, Ming-Zhen LI, Jing CAO. 2013: Body mass, energy budget and leptin of mice under stochastic food restriction and refeeding. Zoological Research, 34(6): 574-581. DOI: 10.11813/j.issn.0254-5853.2013.6.0574

随机限食和重喂食对小鼠体重、能量收支及瘦素的影响

Body mass, energy budget and leptin of mice under stochastic food restriction and refeeding

  • 摘要: 为阐明限食和重喂食(SFR-Re)诱导的体重“补偿性增长”生理机制,该文测定了SFR-Re驯化的KM小鼠能量摄入与支出、身体成分以及血清瘦素水平。结果显示,随机限食使体重显著降低,重喂食后体重增加至对照组水平。驯化结束后,SFR-Re驯化小鼠基础代谢率增加,产热降低,褐色脂肪组织(BAT)细胞色素c氧化酶(COX)活性和解偶联蛋白1(UCP1)水平显著降低,摄入能、消化率和脂肪重量均显著高于自由取食的对照组小鼠,但血清瘦素水平组间差异不显著。即在食物资源丰富的条件下,经历食物短缺的动物将增加能量摄入和消化吸收效率以及脂肪组织能量贮存,从而导致体重的“补偿性增长”,同时,血清瘦素可能在该过程中发挥重要作用。

     

    Abstract: Periods of restricted food intake that lead to lower body weight are often followed by rapid regaining of the lost weight after ad libitum refeeding, an event generally known as the "compensatory growth". To explore the physiological mechanisms underlying "compensatory growth", we evaluated a series of energetic parameters (energy intake, energy expenditure, body composition and serum leptin levels) of adult KM mice subjected to three cycles of stochastic food restriction following by ad libitum refeeding (SFR-Re). The results indicated that animals lost their body mass after stochastic food restriction and then regained to the control level after refeeding. After the final cycle, SFR-Re mice showed higher basal metabolic rate, lower nonshivering thermogenesis, and their cytochrome c oxydase activities, as well as uncoupling protein 1(UCP1) contents of brown adipose tissue all decreased compared with controls. Meanwhile, higher energy intake and digestibility, as well as heavier fat pads also were found in SFR-Re mice. But, serum leptin levels showed no difference between SFR-Re and control mice. On the whole, these findings indicated that when food is resourceful, SFR-Re mice are under rapid "compensatory growth" by increasing their food intake and energy storage efficiency, meanwhile, decreasing energy consumption in thermogenesis. Moreover, leptin may be a possible player in the regulations of energy budget and thermogenesis during "compensatory growth".

     

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