Volume 28 Issue 5
Sep.  2007
Turn off MathJax
Article Contents
LI Hong-bin, HAN Hui-li, MA Wen-pei, DONG Zhi-fang, XU Lin. Enhancement of GABAA Receptor-Mediated Inhibitory Postsynaptic Currents Induced by “Partial Oxygen-Glucose Deprivation”. Zoological Research, 2007, 28(5): 491-496.
Citation: LI Hong-bin, HAN Hui-li, MA Wen-pei, DONG Zhi-fang, XU Lin. Enhancement of GABAA Receptor-Mediated Inhibitory Postsynaptic Currents Induced by “Partial Oxygen-Glucose Deprivation”. Zoological Research, 2007, 28(5): 491-496.

Enhancement of GABAA Receptor-Mediated Inhibitory Postsynaptic Currents Induced by “Partial Oxygen-Glucose Deprivation”

Funds:   
More Information
  • Corresponding author: XU Lin
  • Received Date: 2007-04-03
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2007-10-22
  • Abstract: Oxygen/glucose deprivation (OGD) has been widely used as an in vitro model of focal ischemia, where the blood flow is severely reduced and neurons rapidly die. However, adjacent to the focal region is ‘penumbra’, where residual blood flow remains oxygen and glucose supplies are at low levels. To model this pathological genesis, we developed a partial OGD (pOGD) protocol in a rat brain slice. This model met two requirements: oxygen was partially deprived and glucose was reduced in the perfusion buffer. Therefore we investigated the effect of pOGD on gama-aminobutyric acid (GABAA) receptor-mediated inhibitory postsynaptic currents (IPSCs) in CA1 neurons of a hippocampal slice through whole-cell patch-clamp technique. We found that the amplitude and decay time of IPSCs were increased immediately during pOGD treatment. And the enhancement of IPSCs amplitude resulted from an increase of the synaptic conductance without a significant change in the reversal potential of chloride. These results suggested that the nervous system could increase inhibitory neurotransmission to offset excitation by homeostasis mechanisms during the partial oxygen and glucose attack.
  • loading
  • Relative Articles

    [1] Xian-Hong Ji, Shang-Fei Zhang, Bin Gao, Shun-Yi Zhu. Receptor variability-driven evolution of snake toxins. Zoological Research, 2018, 39(6): 431-436.  doi: 10.24272/j.issn.2095-8137.2018.063
    [2] Chuan-Wang TONG, Zi-Lu WANG, Peng LI, Hui ZHU, Cui-Yun CHEN, Tian-Miao HUA. Effects of senescence on the expression of BDNF and TrkB receptor in the lateral geniculate nucleus of cats. Zoological Research, 2015, 36(1): 48-53.  doi: 10.13918/j.issn.2095-8137.2015.1.48
    [3] WANG Cai-Yun, YANG Shi-Hua. Research on MicroRNAs in pluripotent stem cells. Zoological Research, 2012, 33(4): 416-420.  doi: 10.3724/SP.J.1141.2012.04416
    [4] Zhiheng GOU, Xiao WANG, Wen WANG. Evolution of neurotransmitter gamma-aminobutyric acid, glutamate and their receptors. Zoological Research, 2012, 33(E5-6): 75-81.  doi: 10.3724/SP.J.1141.2012.E05-06E75
    [5] LI Yao, DAI Jie-Jie, SUN Xiao-Mei, XIA Xue-Shan. Progress in studies on HCV receptor of Tupaia as a potential hepatitis C animal model. Zoological Research, 2011, 32(1): 97-103.  doi: 10.3724/SP.J.1141.2011.01097
    [6] LI Qing-jiao, AN Shu-cheng. Involvement of Hippocampal NMDA Receptor and Nitric Oxide Synthase in Depression Induced by Chronic Unpredicted Mild Stress. Zoological Research, 2009, 30(6): 653-661.  doi: 10.3724/SP.J.1141.2009.06653
    [7] YANG Chun, ZHANG Yu-hui, *. Expression of c-fos, Oestradiol and Oestrogen Receptor in the Testis of Rana chensinensis at Different Stages. Zoological Research, 2007, 28(3): 303-310.
    [8] YU Hua-lin , * YE Wen-rui MA Yi-liu WANG Ting-hua FENG Zhong-tang CHEN Ye. Correlation Between Dopamine D2 Receptor in the Orbital Frontal Cortex in Rat and the Processing of Morphine Dependence. Zoological Research, 2006, 27(1): 54-62.
    [9] FANG Yong-qiang, WENG You-zhu, Liu Li-li, FANG Qi, DAI Yan-yu. Mechanism of 5-HT and GnRH Physiological Action in the Ovary of Crassostrea gigas:Orientation of Double Staining and Immunocytochemistry. Zoological Research, 2003, 24(6): 462-466.
    [10] HAN Zhao-jiu, HAN Zhao-jun. Cloning and Sequence of Nicotinic Acetylcholine Receptor α Subunit from Chilo suppressalis. Zoological Research, 2002, 23(1): 7-13.
    [11] DENG Li, ZHANG Wei-Min, LIN Hao-Ran. Research Advances in Growth Hormone Receptor. Zoological Research, 2001, 22(3): 226-230.
    [12] PAN Xing-hua, WANG Shui-qin, CHEN Zhi-long. The Correlations Between Glucocorticoid Receptor and Immune Functions in Cock. Zoological Research, 1998, 19(1): 17-22.
    [13] CHEN Yi-yu, ZHENG Yi-shou, SHI Wei-kang. Immunofluorescent Localization of Epidermal Growth Factor Receptor During Development of Mouse Fetus. Zoological Research, 1992, 13(4): 369-373.
    [14] CHEN Shi-ming, CHI Mu-gen, YANG Yi, XU Xiao-shan. Isolation from Narcine timlei Electroplax of Acetylcholine Receptor-Rich Membrane Vesicles. Zoological Research, 1987, 8(1): 39-46.
    [15] SHE Wei-ming. Characterization of Cytoplasmic Estrogen Receptor in Chicken Oviduct. Zoological Research, 1987, 8(2): 169-176.
    [16] SUN Xin, GONG Chao-liang, PAN Shu-ying, FAN Jian-ying HE Qi-wei. Some Biochemical Properties of the Purified Acetylcholine Receptor Protein From the Electric Organ of Narcine Timlei. Zoological Research, 1985, 6(1): 45-56.
    [17] CHEN Li-jun, SHEN Guo-guang. Purification and Characterization of Acetylcholine Receptor From Narcine Maculata Electroplax. Zoological Research, 1984, 5(2): 199-208.
    [18] HU Ben-rong, SHAN Pau-line, CHEN Ke-min, WU Xiu-rong, CHANG Shi-rong. Isolation and Characterization of Actylcholine Receptor Rich Membrane From Narcine maculata. Zoological Research, 1981, 2(zk): 59-66.
    [19] GONG Chao-liang, SUN Xin, PAN Shu-ying, HE Qi-wei, SONG Shi-lian. Isolation and Purification of the Acetylcholine Receptor From Narcine timlei. Zoological Research, 1981, 2(zk): 51-57.
    [20] TU Lai-hui, ZHANG Ren-chin, QIAO Zhi-ming, YANG Jian. Primary Use of Iodine Labeled Neurotoxin-Acetylcholine Receptor Complex in Myasthenia Gravis Research. Zoological Research, 1980, 1(4): 443-451.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1904) PDF downloads(1923) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return