Volume 19 Issue 2
Mar.  1998
Turn off MathJax
Article Contents
ZHANG Zi-gui, DU Hong-yan, ZHANG Wei-nin, WU Fu-mei. Learning-Memory Dysfunction Caused by High Ca[2+] level and Changes of the Synaptic Interface-Structural Parameters. Zoological Research, 1998, 19(2): 120-124.
Citation: ZHANG Zi-gui, DU Hong-yan, ZHANG Wei-nin, WU Fu-mei. Learning-Memory Dysfunction Caused by High Ca[2+] level and Changes of the Synaptic Interface-Structural Parameters. Zoological Research, 1998, 19(2): 120-124.

Learning-Memory Dysfunction Caused by High Ca[2+] level and Changes of the Synaptic Interface-Structural Parameters

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 1998-04-22
  • In this study,the effect of high Ca[2+] level by injecting CaCl[2] into bilateral hippocampus on the learning and memory behavior of young mice was investigated,and the synaptic structural parameters in the hippocampal CA[3] area were quantitatively analysed.The main results were as follow,compared with control:(1) The STL(step-through latency)of CaCl[2] group was shortened in one trial passive avoidance response,and the descrimination learning capacity of CaCl[2] group in Y-maze was greatly attenuated (P<0.01),showing the severe impairment of learning and memory in this group.(2) The thickness of post-synaptic density (PSD)of CaCl[2] group was thinned significantly (P<0.001),while the width of synaptic cleft of this group was apparently increased (P<0.05).These results suggested that the learning and memory dysfunction caused by over-loaded calcium ions in hippocampus might based on the morphological changes of the synaptic interface stucture.
  • loading
  • Relative Articles

    [1] BIAN Hui, FANG Song, MIAO Ying-Da, YU Hua-Lin. Influences of two different training paradigms on spatial learning and memory performance of hippocampal injured rats. Zoological Research, 2012, (2): 237-240.  doi: 10.3724/SP.J.1141.2012.02237
    [2] HE Xiong, ZHONG Zhao-Ming, CHE Yi. Locomotor activity and learning and memory abilities in Alzheimer’s disease induced by Aluminum in an acid environment in Zebrafish. Zoological Research, 2012, (2): 231-236.  doi: 10.3724/SP.J.1141.2012.02231
    [3] WANG Xiao-Qin, WANG Gong-Wu, DUAN Qiu-Yan, TENG Shi-Tong. Impairment effects of tail suspension stress on spatial memory and its reversal learning in mice. Zoological Research, 2011, 32(4): 428-434.  doi: 10.3724/SP.J.1141.2011.04428
    [4] WANG Jing, ZHOU Qi-Xin, TIAN Men, YANG Yue-Xiong, XU Lin. Tree shrew models: A chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory. Zoological Research, 2011, 32(1): 24-30.  doi: 10.3724/SP.J.1141.2011.01024
    [5] Chen Xin-xin, Yu guo-yu, ZHAN Yan, Zhang Yun, Shen Ji-hong, Lee We. Effects of the Antimicrobial Peptide OH-CATH on Escherichia coli. Zoological Research, 2009, 30(2): 171-177.  doi: 10.3724/SP.J.1141.2009.02171
    [6] ZHANG Jie, YANG Mao-fa. Scanning Electron Microscopy of Antennae of Aphidoletes aphidimyza (Diptera: Cecidomyiidae). Zoological Research, 2008, 29(1): 108-112.
    [7] CHE Yi, CUI Yong-hua, ZHU Yu-fang, XUE Zhi-mou. Founding of Object Recognition Learning Paradigm in KM Mice and Its Application in Detecting Memory Impaired Properties of Compounds. Zoological Research, 2007, 28(5): 497-500.
    [8] MEI Zhen-tong. Study on Learning and Memory of Mutant Mice. Zoological Research, 2000, 21(1): 2-6.
    [9] YUAN Wei-jia, CHEN Lei, PAN Xiao-zhen ZHANG Hui-qi, SHENG Chun. Errects of Calcium Concentration on The Fine Structure of Dark Adapted Photoreceptors in The Crab (Eriocheir sinensis). Zoological Research, 1999, 20(1): 32-35.
    [10] HAN Feng-ying. A Study on The Antennal Sensilla in Dragonflies Using Scanning Electron Microscopy. Zoological Research, 1997, 18(2): 156-162.
    [11] SAI Dao-jian, LI Liu-wen, LIU Lin-ying, SUN Jing-tian, WANG Shu-yun. Observation on The Eggshell of White-Fronted Shearwater With Scanning Electron Microscopy. Zoological Research, 1996, 17(1): 23-26.
    [12] FAN Pei-fang, YE Min-zhong, WIN Ting-huan. Scanning Electron Microscopy Observation on Demodex caprae. Zoological Research, 1996, 17(4): 385-391.
    [13] WANG Liang-bin, ZHANG Wei-ning, SHAO Yue, DU Hong-yan, WANG Jin-xi et al.. Age-Dependent Changes of Synaptosomal Calcium Ions in Different Rat Brain Rigions. Zoological Research, 1995, 16(4): 373-377.
    [14] LI Jun, XU Shi-ting, QU Ying-qi. The Age Characteristics of the Long-Term Synaptic Potentiation in the CA[3] Region of Hippocampus of the Young and The Aged Rats During The Learning. Zoological Research, 1991, 12(3): 285-291.
    [15] ZHENG Wen-biao, PAN Jiong-hua, AN Dong, LIU Wen-sheng. Observations on the Process of fertilization of Clarias lazera By Scanning Electron Microscopy. Zoological Research, 1991, 12(2): 111-115.
    [16] LI Chao-da, YANG Da-rong, SHEN Fa-rong, YANG Yao-xong. Scanning Electron Microscopy of Antennal Sensilla of the Yulong Ghost Moths,Hepialus yulongensis Liang. Zoological Research, 1990, 11(1): 83-86.
    [17] Fang congyi, Liu cheng, Qi huixin, Zheng jianbiao, Chen ling, Xu huiming, Xiang zhongming, Song benbo. The hippocampal formation and learning and memory of dark avoidance behavior in rats IV. effects of colchicine microinjected into various parts of hippocampal formation. Zoological Research, 1988, 9(1): 79-86.
    [18] LIU Ren-yi, HSU Ping-hsuan. Effects on Learning and Memory of Electrolytic Lesions of Hippocampus in Rats. Zoological Research, 1982, 3(4): 385-392.
    [19] GAO Shun-de, ZHANG Hong-wei, HUANG Zhe. Scanning Electron Microscopy Study of the Surface Epithelium of Bursa of Fabricius in Chicken. Zoological Research, 1982, 3(3): 263-267.
    [20] XIA Bang-ying. Observation o the Chorion Structure of Ostrinia Nubilalis and Heliothis Armigera by Scanning and Transmission Electron Microscopy. Zoological Research, 1981, 2(4): 355-361.
  • 加载中


    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1911) PDF downloads(1716) Cited by()
    Proportional views


    DownLoad:  Full-Size Img  PowerPoint