Volume 4 Issue 3
May  1983
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RUAN Chang-geng et al., GU Zhen-lun et al., WANG Wan-yu et al.. The Activation of Platelet Induced by the Venom of Trimeresurus Mucrosquamatus (From Hunan Province). Zoological Research, 1983, 4(3): 245-254.
Citation: RUAN Chang-geng et al., GU Zhen-lun et al., WANG Wan-yu et al.. The Activation of Platelet Induced by the Venom of Trimeresurus Mucrosquamatus (From Hunan Province). Zoological Research, 1983, 4(3): 245-254.

The Activation of Platelet Induced by the Venom of Trimeresurus Mucrosquamatus (From Hunan Province)

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 1983-08-22
  • Trimeresurus Mucrosquamatus venom (TMV) induced the concentration-dependent aggregation of platelets of different species.The threshold concentrations of TMV inducing the platelet aggregation of human,rabbit,dog and Guinea pig were 2.0,12.5,2.0 and 0.6 μg/Ml respectively.EDTA interfered with the platelet aggregation by TMV,but heparin did not prevent the action of TMV.The platelet aggregation induced by TMV was accompanied by the release of serotonin (5-HT) from the challenged platelets.The concentration of TMV which induced the maxium release of 5-HT (72%) from rabbit platelets was 100 μg/Ml.The TMV also induced the formation of Thromboxane A2 (TXA2) of platelets.The inhibition of cyclo-oxygenase with apirin,which reduced and abolished the formation of TXA2,but did not suppress platelt aggregation induced by TMV.Thus,thromboxane-independent mechanisms should account for platelet activation with TMV.Our preliminary results shown that TMV is a good tool for studying the activation of platelets.
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