Yingjie XIA, Shuhua ZHAO, Bingyu MAO. Involvement of XZFP36L1, an RNA-binding protein, in Xenopus neural development. Zoological Research, 2012, 33(E5-6): 82-88. doi: 10.3724/SP.J.1141.2012.E05-06E82
Citation: Yingjie XIA, Shuhua ZHAO, Bingyu MAO. Involvement of XZFP36L1, an RNA-binding protein, in Xenopus neural development. Zoological Research, 2012, 33(E5-6): 82-88. doi: 10.3724/SP.J.1141.2012.E05-06E82

Involvement of XZFP36L1, an RNA-binding protein, in Xenopus neural development

doi: 10.3724/SP.J.1141.2012.E05-06E82
Funds:  This work was supported by National Natural Science Foundation of China (90919039; C120106)
  • Received Date: 2012-08-17
  • Rev Recd Date: 2012-10-15
  • Publish Date: 2012-12-08
  • Xenopus ZFP36L1 (zinc finger protein 36, C3H type-like 1) belongs to the ZFP36 family of RNA-binding proteins, which contains two characteristic tandem CCCH-type zinc-finger domains. The ZFP36 proteins can bind AU-rich elements in 3' untranslated regions of target mRNAs and promote their turnover. However, the expression and role of ZFP36 genes during neural development in Xenopus embryos remains largely unknown. The present study showed that Xenopus ZFP36L1 was expressed at the dorsal part of the forebrain, forebrain-midbrain boundary, and midbrain-hindbrain boundary from late neurula stages to tadpole stages of embryonic development. Overexpression of XZFP36L1 in Xenopus embryos inhibited neural induction and differentiation, leading to severe neural tube defects. The function of XZP36L1 requires both its zinc finger and C terminal domains, which also affect its subcellular localization. These results suggest that XZFP36L1 is likely involved in neural development in Xenopus and might play an important role in post-transcriptional regulation.
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