Volume 33 Issue 6
Nov.  2012
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LI Chao-Hui, GUO Kun, ZHENG Ping. Current progress and future direction in the biology of ovarian germ stem cells in mammals. Zoological Research, 2012, 33(6): 586-590. doi: 10.3724/SP.J.1141.2012.06586
Citation: LI Chao-Hui, GUO Kun, ZHENG Ping. Current progress and future direction in the biology of ovarian germ stem cells in mammals. Zoological Research, 2012, 33(6): 586-590. doi: 10.3724/SP.J.1141.2012.06586

Current progress and future direction in the biology of ovarian germ stem cells in mammals

doi: 10.3724/SP.J.1141.2012.06586
  • Received Date: 2012-09-21
  • Rev Recd Date: 2012-11-18
  • Publish Date: 2012-12-08
  • Whether or not oogenesis continues after birth in mammalian ovaries remains controversial. Since the 1950’s, it has been generally accepted that oogenesis takes place during embryogenesis in mammals and ceases at birth. At birth, germ cells in mammalian ovaries have progressed to the diplotene stage of meiotic prophase and have formed primordial follicles with surrounding somatic cells. These primordial follicles represent follicle reserves of the reproductive life. However, this view has been recently challenged by a growing body of evidence showing the isolation and propagation of germ stem cells from mouse and human ovaries. These ovarian germ stem cells are capable of regenerating functional oocytes when transplanted back into recipient ovaries. Despite the discovery of the potential germ stem cells in mammalian ovaries, it remains uncertain whether these cells exist and function in ovaries under physiological conditions. Herein we review the current progress and future direction in this infant area.
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