Current progress and future direction in the biology of ovarian germ stem cells in mammals

LI Chao-Hui; GUO Kun; ZHENG Ping

doi:10.3724/SP.J.1141.2012.06586

Volume 33 Issue 6

Nov. 2012

Turn off MathJax

Article Contents

Article Navigation > Zoological Research > 2012 > 33(6): 586-590

LI Chao-Hui, GUO Kun, ZHENG Ping. Current progress and future direction in the biology of ovarian germ stem cells in mammals. Zoological Research, 2012, 33(6): 586-590. doi: 10.3724/SP.J.1141.2012.06586

Citation:

LI Chao-Hui, GUO Kun, ZHENG Ping. Current progress and future direction in the biology of ovarian germ stem cells in mammals. Zoological Research, 2012, 33(6): 586-590. doi: 10.3724/SP.J.1141.2012.06586

Citation:

PDF( 0 KB)

Current progress and future direction in the biology of ovarian germ stem cells in mammals

doi: 10.3724/SP.J.1141.2012.06586

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China

Received Date: 2012-09-21
Rev Recd Date: 2012-11-18
Publish Date: 2012-12-08

Abstract

Abstract

Whether or not oogenesis continues after birth in mammalian ovaries remains controversial. Since the 1950’s, it has been generally accepted that oogenesis takes place during embryogenesis in mammals and ceases at birth. At birth, germ cells in mammalian ovaries have progressed to the diplotene stage of meiotic prophase and have formed primordial follicles with surrounding somatic cells. These primordial follicles represent follicle reserves of the reproductive life. However, this view has been recently challenged by a growing body of evidence showing the isolation and propagation of germ stem cells from mouse and human ovaries. These ovarian germ stem cells are capable of regenerating functional oocytes when transplanted back into recipient ovaries. Despite the discovery of the potential germ stem cells in mammalian ovaries, it remains uncertain whether these cells exist and function in ovaries under physiological conditions. Herein we review the current progress and future direction in this infant area.
- Mammals,
- Ovary germ-line stem cells,
- Neo-oogenesis

FullText(HTML)

References(32)

References

[1]	Bazer FW. 2004. Strong science challenges conventional wisdom: new perspectives on ovarian biology[J]. Reprod Biol Endocrinol, 2: 28.
[2]	Begum S, Papaioannou VE, Gosden RG. 2008. The oocyte population is not renewed in transplanted or irradiated adult ovaries[J]. Hum Reprod, 23(10): 2326-2330.
[3]	Bonaguidi MA, Wheeler MA, Shapiro JS, Stadel RP, Sun GJ, Ming GL, Song HJ. 2011. In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics[J]. Cell, 145(7): 1142-1155.
[4]	Bristol-Gould SK, Kreeger PK, Selkirk CG, Kilen SM, Mayo KE, Shea LD, Woodruff TK. 2006. Fate of the initial follicle pool: empirical and mathematical evidence supporting its sufficiency for adult fertility[J]. Dev Biol, 298(1): 149-154.
[5]	Bukovsky A, Svetlikova Mand Caudle MR. 2005. Oogenesis in cultures derived from adult human ovaries[J]. Reprod Biol Endocrinol, 3(1): 17.
[6]	Carlone DL. 2009. Functional analysis of adult stem cells using Cre-mediated lineage tracing[J]. Curr Protoc Stem Cell Biol, Chapter 5: Unit 5A 2.
[7]	Draper BW, McCallum CM, Moens CB. 2007. nanos1 is required to maintain oocyte production in adult zebrafish[J]. Dev Biol, 305(2): 589-598.
[8]	Eggan K, Jurga S, Gosden R, Min IM, Wagers AJ. 2006. Ovulated oocytes in adult mice derive from non-circulating germ cells[J]. Nature, 441(7097): 1109-1114.
[9]	Gosden RG. 1975. Ovarian support of pregnancy in ageing inbred mice[J]. J Reprod Fertil, 42(3): 423-430.
[10]	Gosden RG. 2004. Germline stem cells in the postnatal ovary: is the ovary more like a testis? [J] Hum Reprod Update, 10(3): 193-195.
[11]	Green SH, Zuckerman S. 1951. The number of oocytes in the mature rhesus monkey (Macaca mulatta) [J]. J Endocrinol, 7(2): 194-202.
[12]	Huntriss J, Hinkins M, Picton HM. 2006. cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles[J]. Mol Hum Reprod, 12(5): 283-289.
[13]	Johnson J, Bagley J, Skaznik-Wikiel M, Lee HJ, Adams GB, Niikura Y, Tschudy KS, Tilly JC, Cortes ML, Forkert R, Spitzer T, Iacomini J, Scadden DT, Tilly JL. 2005. Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood[J]. Cell, 122(2): 303-315.
[14]	Johnson J, Canning J, Kaneko T, Pru JK, Tilly JL. 2004. Germline stem cells and follicular renewal in the postnatal mammalian ovary[J]. Nature, 428(6979): 145-150.
[15]	Kerr JB, Duckett R, Myers M, Britt KL, Mladenovska T, Findlay JK. 2006. Quantification of healthy follicles in the neonatal and adult mouse ovary: evidence for maintenance of primordial follicle supply[J]. Reproduction, 132(1): 95-109.
[16]	Kirilly D, Xie T. 2007. The Drosophila ovary: an active stem cell community. Cell Res, 17(1): 15-25.
[17]	Kretzschmar K, Watt FM. 2012. Lineage tracing[J]. Cell, 148(1-2): 33-45.
[18]	Liu YF, Wu C, Lyu QF, Yang DZ, Albertini DF, Keefe DL, Liu L. 2007. Germline stem cells and neo-oogenesis in the adult human ovary[J]. Dev Biol, 306(1): 112-120.
[19]	Nakagawa T, Nabeshima Y, Yoshida S. 2007. Functional identification of the actual and potential stem cell compartments in mouse spermatogenesis[J]. Dev Cell, 12(2): 195-206.
[20]	Nakagawa T, Sharma M, Nabeshima Y, Braun RE, Yoshida S. 2010. Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment[J]. Science, 328(5974): 62-67.
[21]	Niikura Y, Niikura T, Tilly JL. 2009. Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment[J]. Aging (Albany NY), 1(12): 971-978.
[22]	Pearl R. 1917. Studies on the Physiology of Reproduction in the Domestic Fowl. Xvii. the Influence of Age upon Reproductive Ability, with a Description of a New Reproductive Index[J]. Genetics, 2(5): 417-432.
[23]	Skaznik-Wikiel M, Tilly JC, Lee HJ, Niikura Y, Kaneko-Tarui T, Johnson J, Tilly JL. 2007. Serious doubts over "Eggs forever?" [J]. Differentiation, 75(2): 93-99.
[24]	Snippert HJ, Clevers H. 2011. Tracking adult stem cells[J]. EMBO Rep, 12(2): 113-122.
[25]	Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgard R, Clevers H. 2010. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin[J]. Science, 327(5971): 1385-1389.
[26]	Telfer EE. 2004. Germline stem cells in the postnatal mammalian ovary: a phenomenon of prosimian primates and mice[J]? Reprod Biol Endocrinol, 2: 24.
[27]	Vermande-Van Eck GJ. 1956. Neo-ovogenesis in the adult monkey; consequences of atresia of ovocytes[J]. Anat Rec, 125(2): 207-224.
[28]	Virant-Klun I, Zech N, Rozman P, Vogler A, Cvjeticanin B, Klemenc P, Malicev E, Meden-Vrtovec H. 2008. Putative stem cells with an embryonic character isolated from the ovarian surface epithelium of women with no naturally present follicles and oocytes[J]. Differentiation, 76(8): 843-856.
[29]	White YA, Woods DC, Takai Y, Ishihara O, Seki H, Tilly JL. 2012. Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women[J]. Nat Med, 18(3): 413-421.
[30]	Zhang D, Fouad H, Zoma WD, Salama SA, Wentz MJ, Al-Hendy A. 2008. Expression of stem and germ cell markers within nonfollicle structures in adult mouse ovary[J]. Reprod Sci, 15(2): 139-146.
[31]	Zhang H, Zheng W, Shen Y, Adhikari D, Ueno Hand Liu K. 2012. Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries[J]. Proc Natl Acad Sci USA, 109(31): 12580-12585.
[32]	Zou K, Hou L, Sun KJ, Xie WH, Wu J. 2011. Improved efficiency of female germline stem cell purification using fragilis-based magnetic bead sorting[J]. Stem Cells Dev, 20(12): 2197-2204. Zou K, Yuan Z, Yang ZJ, Luo HC, Sun KJ, Zhou L, Xiang J, Shi LJ, Yu QS, Zhang Y, Hou RY. Wu J. 2009. Production of offspring from a germline stem cell line derived from neonatal ovaries[J]. Nat Cell Biol, 11(5): 631-636.