Volume 32 Issue 5
Sep.  2011
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LIU Jian-Tao, YANG Yong, GUO Xiao-Gang, CHEN Miao, DING Huan-Zhong, CHEN Yong-Long. Over-expression of atf4 in Xenopus embryos interferes with neurogenesis and eye formation. Zoological Research, 2011, 32(5): 485-491. doi: 10.3724/SP.J.1141.2011.05485
Citation: LIU Jian-Tao, YANG Yong, GUO Xiao-Gang, CHEN Miao, DING Huan-Zhong, CHEN Yong-Long. Over-expression of atf4 in Xenopus embryos interferes with neurogenesis and eye formation. Zoological Research, 2011, 32(5): 485-491. doi: 10.3724/SP.J.1141.2011.05485

Over-expression of atf4 in Xenopus embryos interferes with neurogenesis and eye formation

doi: 10.3724/SP.J.1141.2011.05485
Funds:  This work was supported in part by funds from the Key Project of Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-083) and the National Basic Research Program of China (2009CB941202)
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  • Author Bio:

    LIU Jian-Tao,YANG Yong

    LIU Jian-Tao,YANG Yong

  • Corresponding author: CHEN Yong-Long,WANG Min-Ru
  • Received Date: 2011-06-23
  • Rev Recd Date: 2011-08-04
  • Publish Date: 2011-10-22
  • Accumulated evidence indicates that the activating transcription factor 4 (atf4) is a developmentally relevant gene. Here, we report on the characterization of atf4 in Xenopus embryos, which is differentially expressed in the central nervous system, eyes, blood, and the pronephros, as well as in developing endodermal organs such as the stomach, duodenum, liver, and pancreas. Ectopic expression of atf4 in the animal hemisphere of Xenopus embryos had no obvious effects on the induction of neural progenitors, but suppressed neurogenesis and eye formation without promoting apoptosis. Our data suggest that tightly controlled atf4 activities may be crucial for normal neurogenesis and early eye patterning.
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