Volume 30 Issue 2
Mar.  2009
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Chen Xin-xin, Yu guo-yu, ZHAN Yan, Zhang Yun, Shen Ji-hong, Lee We. Antibacterial Activity Investigation of Human Semenogelin I Derived Peptides. Zoological Research, 2009, 30(2): 178-184. doi: 10.3724/SP.J.1141.2009.02178
Citation: Chen Xin-xin, Yu guo-yu, ZHAN Yan, Zhang Yun, Shen Ji-hong, Lee We. Antibacterial Activity Investigation of Human Semenogelin I Derived Peptides. Zoological Research, 2009, 30(2): 178-184. doi: 10.3724/SP.J.1141.2009.02178

Antibacterial Activity Investigation of Human Semenogelin I Derived Peptides

doi: 10.3724/SP.J.1141.2009.02178
  • Received Date: 2009-01-16
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2009-04-22
  • SgI-29 is a newly characterized antibacterial peptide derived from human semenogelin I. Using SgI-29 as model, 4 peptides with different length were synthesized. Physico-chemical characteristics and structure prediction of SgI-29 and its derived peptides were analyzed by software packages and helix-wheel plot. The antibacterial activities of SgI-29 and its derived peptides against Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853 were determined. The structure-function relationship of SgI-29 and its derivatives was analyzed. Our results indicated that SgI-22 has the strongest antibacterial activities against the tested bacteria among the synthetic peptides and might be used as a good model for the structure optimization.
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