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Streptozotocin induction of type 2 diabetes in tree shrew

Xiao-Yun WU Yun-Hai LI Qing CHANG Lin-Qiang ZHANG Sha-Sha LIAO Bin LIANG

Xiao-Yun WU, Yun-Hai LI, Qing CHANG, Lin-Qiang ZHANG, Sha-Sha LIAO, Bin LIANG. Streptozotocin induction of type 2 diabetes in tree shrew. Zoological Research, 2013, 34(2): 108-115. doi: 10.3724/SP.J.1141.2013.02108
Citation: Xiao-Yun WU, Yun-Hai LI, Qing CHANG, Lin-Qiang ZHANG, Sha-Sha LIAO, Bin LIANG. Streptozotocin induction of type 2 diabetes in tree shrew. Zoological Research, 2013, 34(2): 108-115. doi: 10.3724/SP.J.1141.2013.02108

链脲佐菌素诱导树鼩2型糖尿病

doi: 10.3724/SP.J.1141.2013.02108
基金项目: 生命科学领域基础前沿研究专项(KSCX2-EW-J-23); 中国科学院知识创新工程重要方向(KSCX2-EW-R-12); “863”计划(2012AA021801, 2012AA022402);西部之光“西部博士”项目(吴晓云);国家自然科学基金(U1202223, Y301261041)
详细信息
  • 中图分类号: Q493.4

Streptozotocin induction of type 2 diabetes in tree shrew

  • 摘要: 链脲佐菌素 (streptozotocin, STZ)是链球菌产生的天然化合物, 对哺乳动物的胰岛B 细胞有特异毒性, 被广泛用于诱导1 型和2 型糖尿病。该研究通过多次小剂量注射STZ 来建立树鼩2 型糖尿病动物模型。24 只树鼩被分为对照组以及60、70和80 mg/kg 剂量STZ 诱导组。注射STZ 后, 成模树鼩出现明显的多饮、多食和多尿症状, 平均体重未减轻, 高血糖症状持续8~16 周, 尿糖显著阳性, 肾功能及糖耐受明显受损, 糖脂代谢紊乱, 但未出现糖尿病乳酸中毒和高血糖高渗等并发症。该结果表明, 多次小剂量STZ 注射可诱导树鼩出现类似2 型糖尿病症状和糖尿病肾脏损伤, 且综合考虑STZ 注射次数、成模率以及成模稳定性, 两次注射80 mg/kg 剂量的STZ 较适合用于创建树鼩2 型糖尿病模型。
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  • 收稿日期:  2012-12-10
  • 修回日期:  2013-01-14
  • 刊出日期:  2013-04-08

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