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TRIMCyp frequency of the cynomolgus macaque (Macaca fascicularis) in captivity in China

Shuai TIAN Yu-Huan MENG Ming-Yu LIU Fei SUN Jun-Hui CHEN Hong-Li DU Xiao-Ning WANG

Shuai TIAN, Yu-Huan MENG, Ming-Yu LIU, Fei SUN, Jun-Hui CHEN, Hong-Li DU, Xiao-Ning WANG. TRIMCyp frequency of the cynomolgus macaque (Macaca fascicularis) in captivity in China. Zoological Research, 2013, 34(2): 97-102. doi: 10.3724/SP.J.1141.2013.02097
Citation: Shuai TIAN, Yu-Huan MENG, Ming-Yu LIU, Fei SUN, Jun-Hui CHEN, Hong-Li DU, Xiao-Ning WANG. TRIMCyp frequency of the cynomolgus macaque (Macaca fascicularis) in captivity in China. Zoological Research, 2013, 34(2): 97-102. doi: 10.3724/SP.J.1141.2013.02097

中国圈养食蟹猴TrimCyp基因频率

doi: 10.3724/SP.J.1141.2013.02097
基金项目: 国家科技重点药物创新与开发重大项目(2011ZX09307-303-03);广州省科学技术计划项目(2009A081000002, 2010B060200007, 2012B060300006);中央高校基础研究基金(2012zz0091, 2012ZZ0093, 2011ZM0111)
详细信息
  • 中图分类号: Q343.1

TRIMCyp frequency of the cynomolgus macaque (Macaca fascicularis) in captivity in China

  • 摘要: TRIM5α在绝大部分的旧大陆猴中扮演抗逆转录病毒的角色, 能够限制HIV-1的活性。TRIMCyp融合基因是继TRIM5α后的另一个抗HIV-1因子研究热点。旧大陆猴的TRIMCyp融合基因是由CypA假基因cDNA序列以逆转录转座的方式插入至TRIM5 基因的3'非翻译区形成, 而且TRIMCyp融合基因在不同灵长类动物中具有地域、基因频率、基因型以及抗逆转病毒效应的差异。虽然食蟹猴TRIMCyp基因的频率在东南亚几个国家或地区已经被初步调查, 但是, 中国大陆食蟹猴养殖场的TRIMCyp基因频率还没有明确阐明。该研究对中国5个省11个养殖场共1 594个食蟹猴 (Macaca fascicularis) 繁殖种群随机样本的TRIMCyp基因频率进行了筛查研究, 发现各场频率略有差异, 从7.65%~19.79%不等, 显著低于已报道的菲律宾、马来西亚和印度尼西亚来源食蟹猴的TRIMCyp基因频率 (34.85%~100%)。该原因可能是由于后者是建立于1978年的封闭群。对带有TRIMCyp融合基因的个体CypA测序发现带有NE单倍型的食蟹猴个体很少, NE单倍型频率 (4.93%)显著低于东南亚三个国家食蟹猴的NE单倍型频率 (11.1%~14.3%)纯合子。该研究为进一步开展食蟹猴HIV-1动物模型和发病机制提供了基础信息。
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  • 收稿日期:  2012-12-05
  • 修回日期:  2013-01-07
  • 刊出日期:  2013-04-08

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