留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina)

Wei PANG Long-Bao LÜ Yun WANG Gui LI Dong-Ti HUANG Ai-Hua LEI Gao-Hong ZHANG Yong-Tang ZHENG

Wei PANG, Long-Bao LÜ, Yun WANG, Gui LI, Dong-Ti HUANG, Ai-Hua LEI, Gao-Hong ZHANG, Yong-Tang ZHENG. Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina). Zoological Research, 2013, 34(2): 89-96. doi: 10.3724/SP.J.1141.2013.02089
Citation: Wei PANG, Long-Bao LÜ, Yun WANG, Gui LI, Dong-Ti HUANG, Ai-Hua LEI, Gao-Hong ZHANG, Yong-Tang ZHENG. Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina). Zoological Research, 2013, 34(2): 89-96. doi: 10.3724/SP.J.1141.2013.02089

北平顶猴(Macaca leonina)血液学和血液生化指标参考值的测定与分析

doi: 10.3724/SP.J.1141.2013.02089
基金项目: 国家自然科学基金 (81172876, U0832601, 81273251, U1202228);国家重大科学研究计划课题 (2012CBA01305);国家科技重大专项课题 (2013ZX10001-002);中国科学院知识创新工程重要方向 (KSCX2-EW-R-13)
详细信息
  • 中图分类号: Q955;Q952;Q95-3

Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina)

  • 摘要: 平顶猴是重要的非人灵长类实验动物, 广泛应用于艾滋病等重大疾病的动物模型研究。平顶猴分为明打威猴、巽他平顶猴和北平顶猴三个种。我国及周边东南亚国家分布的平顶猴为北平顶猴。该文测定和分析了青幼年 (2~4 a) 和成年 (5~10 a) 北平顶猴的血液学和血液生化指标参考值。结果表明个体性别、年龄和体重等对该指标均有影响。雌性个体的红细胞数、血红蛋白和碱性磷酸酶均低于雄性个体。青幼年个体的白细胞数、淋巴细胞数、单核细胞数、血小板分布宽度、碱性磷酸酶、天冬氨酸转氨酶和胆固醇均高于成年猴, 而肌酐和甘油三酯则低于成年猴。个体体重与青年猴的平均血红蛋白含量和肌酐正相关, 与成年猴的平均血红蛋白含量、粒细胞百分比、血红蛋白和肌酐正相关, 而与成年猴的淋巴细胞数、淋巴细胞百分比、红细胞分布宽度变异系数、天冬氨酸转氨酶和胆固醇负相关。该研究提供的北平顶猴血液学和血液生化指标参考值范围, 对其基础研究、疾病诊断和模型建立等具有重要意义。
  • [1] Agy MB, Frumkin LR, Corey L, Coombs RW, Wolinsky SM, Koehler J, Morton WR, Katze MG. 1992. Infection of Macaca nemestrina by human immunodeficiency virus type-1. Science, 257(5066): 103-106.
    [2] Balagopal A, Gama L, Franco V, Russell JN, Quinn J, Higgins Y, Smeaton LM, Clements JE, Thomas DL, Gupta A; NWCS 319 and ACTG 5175 study team. 2012. Detection of microbial translocation in HIV and SIV infection using the Limulus amebocyte lysate assay is masked by serum and plasma. PLoS One, 7(8): e41258.
    [3] Brennan G, Kozyrev Y, Hu SL. 2008. TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis. Proceedings of the National Academy of Sciences of the United States of America, 105(9): 3569-3574.
    [4] Cao G, Liu FL, Zhang GH, Zheng YT. 2012. The primate TRIMCyp fusion genes and mechanism of restricting retroviruses replication. Zoological Research, 33(1): 99-107 [曹光, 刘丰亮, 张高红, 郑永唐. 2012. 灵长类动物中TRIMCyp融合基因模式及对逆转录病毒复制的限制作用. 动物学研究, 33(1): 99-107].
    [5] Cao G, Nie WH, Liu FL, Kuang YQ, Wang JH, Su WT, Zheng YT. 2011. Identification of the TRIM5/TRIMCyp heterozygous genotype in Macaca assamensis. Zoological Research, 32(1): 40-49. [曹光, 佴文惠, 刘丰亮, 况轶群, 王金焕, 苏伟婷, 郑永唐. 2011. 熊猴存在TRIM5/TRIMCyp杂合子基因型. 动物学研究, 2011, 32(1): 40-49.]
    [6] Chen Y, Qin S, Ding Y, Wei L, Zhang J, Li H, Bu H, Lu Y, Cheng J. 2009. Reference values of clinical chemistry and hematology parameters in rhesus monkeys (Macaca mulatta). Xenotransplantation, 16(6): 496-501.
    [7] Dai J, Tang D, Lu S, Kuang D, Yang F, Cheng S, Huang R. 2000. Clinical normal values of hematology and serum biochemistry in domestically bred and reared rhesus monkeys. Acta Laboratorium Scientia Sinica, 8(4): 224-230. [代解杰, 唐东红, 鲁帅尧, 匡德宣, 杨帆, 树军, 黄韧. 2000. 人工饲养条件下恒河猴血液学、血液生化正常参考值测定及分析. 中国实验动物学报, 8(4): 224-230.]
    [8] Gippoliti S. 2001. Notes on the taxonomy of Macaca nemestrina leonina blyth, 1863 (Primates: Cercopithecidae). Hystrix, the Italian Journal of Mammalog, 12(1): 51-54.
    [9] Groves CP. 2001. Primate Taxonomy. Washington, DC, USA: Smithsonian Institution Press, 222-224.
    [10] Haberthur K, Engelman F, Barron A, Messaoudi I. 2010. Immune senescence in aged nonhuman primates. Experimental Gerontology, 45(9): 655-661.
    [11] Hatziioannou T, Evans DT. 2012. Animal models for HIV/AIDS research. Nature Reviews Microbiology, 10(12): 852-867.
    [12] Hukkanen RR, Liggitt HD, Anderson DM, Kelley ST. 2006. Detection of systemic amyloidosis in the pig-tailed macaque (Macaca nemestrina). Comparative Medicine, 56(2): 119-127.
    [13] Kuang YQ, Tang X, Liu FL, Jiang XL, Zhang YP, Gao GX, Zheng YT. 2009. Genotyping of TRIM5 locus in northern pig-tailed macaques (Macaca leonina), a primate species susceptible to Human Immunodeficiency Virus type 1 infection. Retrovirology, 6(1): 58.
    [14] Lee JI, Shin JS, Lee JE, Jung WY, Lee G, Kim MS, Park CG, Kim SJ. 2012. Reference values of hematology, chemistry, electrolytes, blood gas, coagulation time, and urinalysis in the Chinese rhesus macaques (Macaca mulatta). Xenotransplantation, 19(4): 244-248.
    [15] Lei AH, Pang W, Zhang GH, Zheng YT. 2013. The use and research of pigtailed macaques for AIDS nonhuman primate models: An overview. Zoological Research, 34(2): 77-88. [雷爱华, 庞伟, 张高红, 郑永唐. 2013. 平顶猴在HIV/AIDS动物模型中的应用及研究进展. 动物学研究, 34(2): 77-88.]
    [16] Liao CH, Kuang YQ, Liu HL, Zheng YT, Su B. 2007. A novel fusion gene, TRIM5-Cyclophilin A in the pig-tailed macaque determines its susceptibility to HIV-1 infection. AIDS, 21(Suppl 8): S19-S26.
    [17] Liu SG, Xie L. 2012. Measurement of hematological and serum biochemical parameters in feeding population of cynomolgus monkey in Eastern China. Laboratory Animal Science, 2(4): 34-37. [刘仕刚, 谢亮. 2012. 华东地区人工饲养食蟹猴血液常规和血清生化值的测定. 实验动物科学, 2(4): 34-37.]
    [18] Macellini S, Ferrari PF, Bonini L, Fogassi L, Paukner A. 2010. A modified mark test for own-body recognition in pig-tailed macaques (Macaca nemestrina). Animal Cognition, 13(4): 631-639.
    [19] Malaivijitnond S, Arsaithamkul V, Tanaka H, Pomchote P, Jaroenporn S, Suryobroto B, Hamada Y. 2012. Boundary zone between northern and southern pig-tailed macaques and their morphological differences. Primates, 53(4): 377-389.
    [20] Moss JA, Malone AM, Smith TJ, Butkyavichene I, Cortez C, Gilman J, Kennedy S, Kopin E, Nguyen C, Sinha P, Hendry RM, Guenthner P, Holder A, Martin A, McNicholl J, Mitchell J, Pau CP, Srinivasan P, Smith JM, Baum MM. 2012. Safety and pharmacokinetics of intravaginal rings delivering tenofovir in pig-tailed macaques. Antimicrobial Agents and Chemotherapy, 56(11): 5952-5960.
    [21] Newman RM, Hall L, Kirmaier A, Pozzi LA, Pery E, Farzan M, O'Neil SP, Johnson W. 2008. Evolution of a TRIM5-CypA splice isoform in old world monkeys. PLoS Pathogens, 4(2): e1000003.
    [22] Patton DL, Sweeney YT, Paul KJ. 2009. A summary of preclinical topical microbicide rectal safety and efficacy evaluations in a pigtailed macaque model. Sexually Transmitted Diseases, 36(6): 350-356.
    [23] Reeves RK, Fultz PN. 2008. Characterization of plasmacytoid dendritic cells in bone marrow of pig-tailed macaques. Clinical and Vaccine Immunology, 15(1): 35-41.
    [24] Schuurman HJ, Smith HT. 2005. Reference values for clinical chemistry and clinical hematology parameters in cynomolgus monkeys. Xenotransplantation, 12(1): 72-75.
    [25] Smucny DA, Allison DB, Ingram DK, Roth GS, Kemnitz JW, Kohama SG, Lane MA, Black A. 2004. Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta). Journal of Medical Primatology, 33(1): 48-54.
    [26] Tosi AJ, Morales JC, Melnick DJ. 2000. Comparison of Y chromosome and mtDNA phylogenies leads to unique inferences of macaque evolutionary history. Molecular Phylogenetics and Evolution, 17(2): 133-144.
    [27] Virgen CA, Kratovac Z, Bieniasz PD, Hatziioannou T. 2008. Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species. Proceedings of the National Academy of Sciences of the United States of America, 105(9): 3563-3568.
    [28] Weed MR, Wilcox KM, Ator NA, Hienz RD. 2008. Consistent, high-level ethanol consumption in pig-tailed macaques via a multiple-session, limited- intake, oral self-dosing procedure. Alcoholism: Clinical Experimental Research, 32(6): 942-951.
    [29] Wilson SJ, Webb BL, Ylinen LM, Verschoor E, Heeney JL, Towers GJ. 2008. Independent evolution of an antiviral TRIMCyp in rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America, 105(9): 3557-3562.
  • [1] Ming-Xu Zhang, Tian-Zhang Song, Hong-Yi Zheng, Xue-Hui Wang, Ying Lu, Han-Dan Zhang, Ting Li, Wei Pang, Yong-Tang Zheng.  Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina), Zoological Research. doi: 10.24272/j.issn.2095-8137.2019.047
    [2] Mei-Ling Zhang, Ming-Li Li, Adeola Oluwakemi Ayoola, Robert W. Murphy, Dong-Dong Wu, Yong Shao.  Conserved sequences identify the closest living relatives of primates, Zoological Research. doi: 10.24272/j.issn.2095-8137.2019.057
    [3] Tian-Zhang Song, Ming-Xu Zhang, Yu-Jie Xia, Yu Xiao, Wei Pang, Yong-Tang Zheng.  Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239, Zoological Research. doi: 10.24272/j.issn.2095-8137.2018.015
    [4] Xiao-Liang ZHANG, Jia-Hao SONG, Wei PANG, Yong-Tang ZHENG.  Molecular cloning and anti-HIV-1 activities of APOBEC3s from northern pig-tailed macaques (Macaca leonina), Zoological Research. doi: 10.13918/j.issn.2095-8137.2016.4.246
    [5] Lin ZHU, Ai-Hua LEI, Hong-Yi ZHENG, Long-Bao LYU, Zhi-Gang ZHANG, Yong-Tang ZHENG.  Longitudinal analysis reveals characteristically high proportions of bacterial vaginosis-associated bacteria and temporal variability of vaginal microbiota in northern pig-tailed macaques (Macaca leonina), Zoological Research. doi: 10.13918/j.issn.2095-8137.2015.5.285
    [6] Xiao-Liang ZHANG, Wei PANG, Xin-Tian HU, Jia-Li LI, Yong-Gang YAO, Yong-Tang ZHENG.  Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress, Zoological Research. doi: 10.13918/j.issn.2095-8137.2014.6.447
    [7] Hong-Yi ZHENG, Ming-Xu ZHANG, Lin-Tao ZHANG, Xiao-Liang ZHANG, Wei PANG, Long-Bao LYU, Yong-Tang ZHENG.  Flow cytometric characterizations of leukocyte subpopulations in the peripheral blood of northern pig-tailed macaques (Macaca leonina), Zoological Research. doi: 10.13918/j.issn.2095-8137.2014.6.465
    [8] Xiao-Liang ZHANG, Wei PANG, De-Yao DENG, Long-Bao LV, Yue FENG, Yong-Tang ZHENG.  Analysis of immunoglobulin, complements and CRP levels in serum of captive northern pig-tailed macaques (Macaca leonina), Zoological Research. doi: 10.11813/j.issn.0254-5853.2014.3.196
    [9] Ai-Hua LEI, Gao-Hong ZHANG, Ren-Rong TIAN, Jia-Wu ZHU, Hong-Yi ZHENG, Wei PANG, Yong-Tang ZHENG.  Replication potentials of HIV-1/HSIV in PBMCs from northern pig-tailed macaque (Macaca leonina), Zoological Research. doi: 10.11813/j.issn.0254-5853.2014.3.186
    [10] Special Issue for Primates and Animal Models of Human Diseases, Zoological Research.
    [11] DONG Li, LÜ Long-Bao, LAI Ren.  Molecular cloning of Tupaia belangeri chinensis neuropeptide Y and homology comparison with other analogues from primates, Zoological Research. doi: 10.3724/SP.J.1141.2012.01075
    [12] Liang ZHAO, Xingtao ZHANG, Xingkui TAO, Weiwei WANG, Ming LI.  Preliminary analysis of the mitochondrial genome evolutionary pattern in primates, Zoological Research. doi: 10.3724/SP.J.1141.2012.E03-04E47
    [13] PAN Ru-Lian, Charles Oxnard.  Craniodental Variation of Macaques (Macaca):Size,Function and Phylogeny, Zoological Research.
    [14] WU Han-lin, CHEN Yong-hao.  An Animal Experimental Study of Acute Intoxication With Cyprinids Bile, Zoological Research.
    [15] DUAN Xing-sheng, LI Shao-dong, LIU Jang-hai, HU Li-ya.  The Investigation on Hematologic and Hemachemical Parameters of three species in Macaca, Zoological Research.
    [16] FAN Ji-rui, MIAO Ying-da, MA Yuan-ye, CAI Jing-xia, XU Lin, XIAO Kun-yuan.  The Computer System Used in Primate Brain Research, Zoological Research.
    [17] YE Zhi-zhang, PAN Ru-liang, PENG Yan-zhang.  The Major Characteristics of Musculature on The Upper and Lower Limbs in Francois' and Phayre's Leaf Monkeys, Zoological Research.
    [18] YE Zhi-zhang, PAN Ru-liang, PENG Yan-zhang.  Arterial System of Erancois'and Phayre's Leaf Monkeys, Zoological Research.
    [19] ZHANG Yao-ping, WANG Jing-song, YAN Qing-ming et al..  Studies on the Hemagram and Myelogram of Pig-Tailed Macaque (Macaca nemestrina), Zoological Research.
    [20] BEN Kun-long, DAI Wei, SONG Bao-yun, ZHOU Ru-jing.  Studies on Lymphocyte Subpoulations in Primates Ⅰ.The Determination of SRBC,SMRBC and ZYC Rosette Formation Cell in Peripheral Blood and Lymphoid Tissues, Zoological Research.
  • 加载中
计量
  • 文章访问数:  1568
  • HTML全文浏览量:  25
  • PDF下载量:  3232
  • 被引次数: 0
出版历程
  • 收稿日期:  2013-01-21
  • 修回日期:  2013-02-09
  • 刊出日期:  2013-04-08

目录

    /

    返回文章
    返回