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Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina)

Wei PANG Long-Bao LÜ Yun WANG Gui LI Dong-Ti HUANG Ai-Hua LEI Gao-Hong ZHANG Yong-Tang ZHENG

Wei PANG, Long-Bao LÜ, Yun WANG, Gui LI, Dong-Ti HUANG, Ai-Hua LEI, Gao-Hong ZHANG, Yong-Tang ZHENG. Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina). Zoological Research, 2013, 34(2): 89-96. doi: 10.3724/SP.J.1141.2013.02089
Citation: Wei PANG, Long-Bao LÜ, Yun WANG, Gui LI, Dong-Ti HUANG, Ai-Hua LEI, Gao-Hong ZHANG, Yong-Tang ZHENG. Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina). Zoological Research, 2013, 34(2): 89-96. doi: 10.3724/SP.J.1141.2013.02089

北平顶猴(Macaca leonina)血液学和血液生化指标参考值的测定与分析

doi: 10.3724/SP.J.1141.2013.02089
基金项目: 国家自然科学基金 (81172876, U0832601, 81273251, U1202228);国家重大科学研究计划课题 (2012CBA01305);国家科技重大专项课题 (2013ZX10001-002);中国科学院知识创新工程重要方向 (KSCX2-EW-R-13)
  • 中图分类号: Q955;Q952;Q95-3

Measurement and analysis of hematology and blood chemistry parameters in northern pig-tailed macaques (Macaca leonina)

  • 摘要: 平顶猴是重要的非人灵长类实验动物, 广泛应用于艾滋病等重大疾病的动物模型研究。平顶猴分为明打威猴、巽他平顶猴和北平顶猴三个种。我国及周边东南亚国家分布的平顶猴为北平顶猴。该文测定和分析了青幼年 (2~4 a) 和成年 (5~10 a) 北平顶猴的血液学和血液生化指标参考值。结果表明个体性别、年龄和体重等对该指标均有影响。雌性个体的红细胞数、血红蛋白和碱性磷酸酶均低于雄性个体。青幼年个体的白细胞数、淋巴细胞数、单核细胞数、血小板分布宽度、碱性磷酸酶、天冬氨酸转氨酶和胆固醇均高于成年猴, 而肌酐和甘油三酯则低于成年猴。个体体重与青年猴的平均血红蛋白含量和肌酐正相关, 与成年猴的平均血红蛋白含量、粒细胞百分比、血红蛋白和肌酐正相关, 而与成年猴的淋巴细胞数、淋巴细胞百分比、红细胞分布宽度变异系数、天冬氨酸转氨酶和胆固醇负相关。该研究提供的北平顶猴血液学和血液生化指标参考值范围, 对其基础研究、疾病诊断和模型建立等具有重要意义。
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  • 收稿日期:  2013-01-21
  • 修回日期:  2013-02-09
  • 刊出日期:  2013-04-08