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Use and research of pigtailed macaques in nonhuman primate HIV/AIDS models

Ai-Hua LEI Wei PANG Gao-Hong ZHANG Yong-Tang ZHENG

Ai-Hua LEI, Wei PANG, Gao-Hong ZHANG, Yong-Tang ZHENG. Use and research of pigtailed macaques in nonhuman primate HIV/AIDS models. Zoological Research, 2013, 34(2): 77-88. doi: 10.3724/SP.J.1141.2013.02077
Citation: Ai-Hua LEI, Wei PANG, Gao-Hong ZHANG, Yong-Tang ZHENG. Use and research of pigtailed macaques in nonhuman primate HIV/AIDS models. Zoological Research, 2013, 34(2): 77-88. doi: 10.3724/SP.J.1141.2013.02077

平顶猴在HIV/AIDS 动物模型中的应用及研究进展

doi: 10.3724/SP.J.1141.2013.02077
基金项目: 国家自然科学基金 (81172876, U0832601, 81273251, U1202228);国家重大科学研究计划 (2012CBA01305);国家科技重大专项(2013ZX10001-002)和中国科学院知识创新工程重要方向 (KSCX2-EW-R-13)
详细信息
  • 中图分类号: Q291;Q959.848

Use and research of pigtailed macaques in nonhuman primate HIV/AIDS models

  • 摘要: 非人灵长类动物模型在HIV-1 致病机制研究以及抗AIDS 药物和疫苗研发中具有重要作用。由于缺乏HIV-1 直接感染的动物, SIV/SHIV 猕猴模型是目前AIDS 研究中应用最为广泛的动物模型。虽然SIV/SHIV 猕猴模型与人AIDS 具有一定的相似性, 但SIV/SHIV 与HIV-1 间的遗传差异较大, 致使SIV/SHIV 猕猴模型存在很多局限性。创建合适的非人灵长类动物模型仍然是HIV/AIDS 研究中的热点和难点。平顶猴是目前唯一可以被HIV-1 感染的旧大陆猴, 在HIV-1 静脉传播和性传播模型研究中具有许多优势。该文综述了SIV、HIV、SHIV 和HSIV 通过静脉和黏膜途径感染平顶猴的特征, 并简要介绍了病毒在平顶猴细胞中复制的分子机制以及建立平顶猴AIDS 模型的限制因素和前景。
  • [1] Agy MB, Frumkin LR, Corey L, Coombs RW, Wolinsky SM, Koehler J, Morton WR, Katze MG. 1992. Infection of Macaca nemestrina by human immunodeficiency virus type-1. Science, 257(5066): 103-106.
    [2] Agy MB, Schmidt A, Florey MJ, Kennedy BJ, Schaefer G, Katze MG, Corey L, Morton WR, Bosch ML. 1997. Serial in vivo passage of HIV-1 infection in Macaca nemestrina. Virology, 238(2): 336-343.
    [3] Albin JS, Harris RS. 2010. Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics. Expert Reviews in Molecular Medicine, 12: e4.
    [4] Ambrose Z, KewalRamani VN, Bieniasz PD, Hatziioannou T. 2007. HIV/AIDS: in search of an animal model. Trends in Biotechnology, 25(8): 333-337.
    [5] Ambrose Z, Larsen K, Thompson J, Stevens Y, Finn E, Hu SL, Bosch ML. 2001. Evidence for early local viral replication and local production of antiviral immunity upon mucosal simian-human immunodeficiency virus SHIV89.6 infection in Macaca nemestrina. Journal of Virology, 75(18): 8589-8596.
    [6] Baldauf HM, Pan XY, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, Konig R, Fackler OT, Keppler OT. 2012. SAMHD1 restricts HIV-1 infection in resting CD4+ T cells. Nature Medicine, 18(11): 1682-1689.
    [7] Baroncelli S, Negri DR, Michelini Z, Cara A. 2008. Macaca mulatta, fascicularis and nemestrina in AIDS vaccine development. Expert Review of Vaccines, 7(9): 1419-1434.
    [8] Batten CJ, De Rose R, Wilson KM, Agy MB, Chea S, Stratov I, Montefiori DC, Kent SJ. 2006. Comparative evaluation of simian, simian-human, and human immunodeficiency virus infections in the pigtail macaque (Macaca nemestrina) model. AIDS Research and Human Retroviruses, 22(6): 580-588.
    [9] Beer BE, Brown CR, Whitted S, Goldstein S, Goeken R, Plishka R, Buckler-White A, Hirsch VM. 2005. Immunodeficiency in the absence of high viral load in pig-tailed macaques infected with Simian immunodeficiency virus SIVsun or SIVlhoest. Journal of Virology, 79(22): 14044-14056.
    [10] Belshan M, Kimata JT, Brown C, Cheng XG, McCulley A, Larsen A, Thippeshappa R, Hodara V, Giavedoni L, Hirsch V, Ratner L. 2012. Vpx is critical for SIVmne infection of pigtail macaques. Retrovirology, 9(1): 32.
    [11] Benveniste RE, Morton WR, Clark EA, Tsai CC, Ochs HD, Ward JM, Kuller L, Knott WB, Hill RW, Gale MJ. 1988. Inoculation of baboons and macaques with simian immunodeficiency virus/Mne, a primate lentivirus closely related to human immunodeficiency virus type 2. Journal of Virology, 62(6): 2091-2101.
    [12] Blanco-Melo D, Venkatesh S, Bieniasz PD. 2012. Intrinsic cellular defenses against human immunodeficiency viruses. Immunity, 37(3): 399-411.
    [13] Bosch ML, Schmidt A, Agy MB, Kimball LE, Morton WR. 1997. Infection of Macaca nemestrina neonates with HIV-1 via different routes of inoculation. AIDS, 11(13): 1555-1563.
    [14] Bosch ML, Schmidt A, Chen JL, Florey MJ, Agy M, Morton WR. 2000. Enhanced replication of HIV-1 in vivo in pigtailed macaques (Macaca nemestrina). Journal of Medical Primatology, 29(3-4): 107-113.
    [15] Brennan G, Kozyrev Y, Kodama T, Hu SL. 2007. Novel TRIM5 isoforms expressed by Macaca nemestrina. Journal of Virology, 81(22): 12210-12217.
    [16] Cao G, Liu FL, Zhang GH, Zheng YT. 2012. The primate TRIMCyp fusion genes and mechanism of restricting retroviruses replication. Zoological Research, 33(1): 99-107 [曹光, 刘丰亮, 张高红, 郑永唐. 2012. 灵长类动物中TRIMCyp融合基因模式及对逆转录病毒复制的限制作用. 动物学研究, 33(1): 99-107]
    [17] Chiu YL, Greene WC. 2008. The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. Annual Review of Immunology, 26(1): 317-353.
    [18] Couedel-Courteille A, Pretet JL, Barget N, Jacques S, Petitprez K, Tulliez M, Guillet JG, Venet A, Butor C. 2003. Delayed viral replication and CD4+ T cell depletion in the rectosigmoid mucosa of macaques during primary rectal SIV infection. Virology, 316(2): 290-301.
    [19] Dai ZX, Zhang GH, Zheng YT. 2008. Advances in research of rhesus macaque MHC and its significance in animal models of AIDS. International Journal of Immunology, 31(5): 334-339. [戴正喜, 张高红, 郑永唐. 2008. 猕猴MHC研究及在AIDS动物模型中的意义. 国际免疫学杂志, 31(5): 334-339.]
    [20] Endsley AN, Ho RJ. 2012. Elucidation of the time course of adenosine deaminase APOBEC3G and viral infectivity factor vif in HIV-2287-infected infant macaques. Journal of Medical Primatology, 41(1): 52-59.
    [21] Gippoliti S. 2001. Notes on the taxonomy of Macaca nemestrina leonina blyth, 1863 (Primates: Cercopithecidae). Hystrix-Italian Journal of Mammalogy, 12(1): 51-54.
    [22] Goldstein S, Ourmanov I, Brown CR, Plishka R, Buckler-White A, Byrum R, Hirsch VM. 2005. Plateau levels of viremia correlate with the degree of CD4+-T-cell loss in simian immunodeficiency virus SIVagm-infected pigtailed macaques: variable pathogenicity of natural SIVagm isolates. Journal of Virology, 79(8): 5153-5162.
    [23] Groves CP. 2001. Primate Taxonomy. Washington DC: Smithsonian Institution Press, 222-224.
    [24] Hatziioannou T, Evans DT. 2012. Animal models for HIV/AIDS research. Nature Reviews Microbiology, 10(12): 852-867.
    [25] Hatziioannou T, Princiotta M, Piatak M, Yuan F, Zhang FW, Lifson JD, Bieniasz PD. 2006. Generation of simian-tropic HIV-1 by restriction factor evasion. Science, 314(5796): 95.
    [26] Hatziioannou T, Ambrose Z, Chung NPY, Piatak M, Yuan F, Trubey CM, Coalter V, Kiser R, Schneider D, Smedley J, Pung R, Gathuka M, Estes JD, Veazey RS, KewalRamani VN, Lifson JD, Bieniasz PD. 2009. A macaque model of HIV-1 infection. Proceedings of the Natlonal Academy of Sciences United States of America, 106(11): 4425-4429.
    [27] Henning T, Fakile Y, Phillips C, Sweeney E, Mitchell J, Patton D, Sturdevant G, Caldwell HD, Secor WE, Papp J, Hendry RM, McNicholl J, Kersh E. 2011. Development of a pigtail macaque model of sexually transmitted infection/HIV coinfection using Chlamydia trachomatis, Trichomonas vaginalis, and SHIVSF162P3. Journal of Medical Primatology, 40(4): 214-223.
    [28] Hirsch VM, Johnson PR. 1994. Pathogenic diversity of simian immunodeficiency viruses. Virus Research, 32(2): 183-203.
    [29] Hu SL. 2005. Non-human primate models for AIDS vaccine research. Current Drug Targets Infectious Disorders, 5(2): 193-201.
    [30] Humes D, Overbaugh J. 2011. Adaptation of subtype a human immunodeficiency virus type 1 envelope to pig-tailed macaque cells. Journal of Virology, 85(9): 4409-4420.
    [31] Igarashi T, Iyengar R, Byrum RA, Buckler-White A, Dewar RL, Buckler CE, Lane HC, Kamada K, Adachi A, Martin MA. 2007. Human immunodeficiency virus type 1 derivative with 7% simian immunodeficiency virus genetic content is able to establish infections in pig-tailed macaques. Journal of Virology, 81(20): 11549-11552.
    [32] Jiang YH, Tian BP, Saifuddin M, Agy MB, Emau P, Cairns JS, Tsai CC. 2009. RT-SHIV, an infectious CCR5-tropic chimeric virus suitable for evaluating HIV reverse transcriptase inhibitors in macaque models. AIDS Research and Therapy, 6(1): 23.
    [33] Joag SV, Li Z, Foresman L, Pinson DM, Raghavan R, Zhuge W, Adany I, Wang C, Jia F, Sheffer D, Ranchalis J, Watson A, Narayan O. 1997. Characterization of the pathogenic KU-SHIV model of acquired immunodeficiency syndrome in macaques. AIDS Research and Human Retroviruses, 13(8): 635-645.
    [34] Kamada K, Igarashi T, Martin MA, Khamsri B, Hatcho K, Yamashita T, Fujita M, Uchiyama T, Adachi A. 2006. Generation of HIV-1 derivatives that productively infect macaque monkey lymphoid cells. Proceedings of the National Academy of Sciences of the United States of America, 103(45): 16959-16964.
    [35] Kent SJ, Woodward A, Zhao A. 1997. Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses correlate with control of acute HIV-1 infection in macaques. The Journal of Infectious Diseases, 176(5): 1188-1197.
    [36] Kent SJ, Corey L, Agy MB, Morton WR, McElrath MJ, Greenberg PD. 1995. Cytotoxic and proliferative T cell responses in HIV-1-infected Macaca nemestrina. Journal of Clinical Investigation, 95(1): 248-256.
    [37] Kent SJ, Dale CJ, Preiss S, Mills J, Campagna D, Purcell DF. 2001. Vaccination with attenuated simian immunodeficiency virus by DNA inoculation. Journal of Virology, 75(23): 11930-11934.
    [38] Kent SJ, Dale CJ, Ranasinghe C, Stratov I, De Rose R, Chea S, Montefiori DC, Thomson S, Ramshaw IA, Coupar BE, Boyle DB, Law M, Wilson KM, Ramsay AJ. 2005. Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3. Vaccine, 23(42): 5009-5021.
    [39] Klatt NR, Silvestri G, Hirsch V. 2012b. Nonpathogenic simian immunodeficiency virus infections. Cold Spring Harbor Perspectives in Medicine, 2(1): a007153.
    [40] Klatt NR, Canary LA, Vanderford TH, Vinton CL, Engram JC, Dunham RM, Cronise HE, Swerczek JM, Lafont BA, Picker LJ, Silvestri G, Brenchley JM. 2012a. Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques. Journal of Virology, 86(2): 1203-1213.
    [41] Klatt NR, Harris LD, Vinton CL, Sung H, Briant JA, Tabb B, Morcock D, McGinty JW, Lifson JD, Lafont BA, Martin MA, Levine AD, Estes JD, Brenchley JM. 2010. Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection. Mucosal Immunology, 3(4): 387-398.
    [42] Kuang YQ, Tang X, Liu FL, Jiang XL, Zhang YP, Gao GX, Zheng YT. 2009. Genotyping of TRIM5 locus in northern pig-tailed macaques (Macaca leonina), a primate species susceptible to Human Immunodeficiency Virus type 1 infection. Retrovirology, 6(1): 58.
    [43] Kuller L, Schmidt A, Mack H, Durning M, Birkebak T, Reiner MT, Anderson DM, Morton WR, Agy MB. 2001. Systemic and intestinal immune responses to HIV-2287 infection in Macaca nemestrina. AIDS Research and Human Retroviruses, 17(12): 1191-1204.
    [44] Kuroishi A, Saito A, Shingai Y, Shioda T, Nomaguchi M, Adachi A, Akari H, Nakayama EE. 2009. Modification of a loop sequence between alpha-helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV-1) derivative that has simian immunodeficiency virus (SIVmac239) vif and CA alpha-helices 4 and 5 loop improves replication in cynomolgus monkey cells. Retrovirology, 6(1): 70.
    [45] Lackner AA, Veazey RS. 2007. Current concepts in AIDS pathogenesis: insights from the SIV/macaque model. Annual Review of Medicine, 58(1): 461-476.
    [46] Laurén A, V?dr?s D, Thorstensson R, Feny? EM. 2006. Comparative studies on mucosal and intravenous transmission of simian immunodeficiency virus (SIVsm): evolution of coreceptor use varies with pathogenic outcome. Journal of General Virology, 87(Pt 3): 581-594.
    [47] Li MH, Zhang GH, Sun T, Zheng YT. 2007a. The value of nonhuman primate animal models in anti-HIV drug studies. Chinese Journal of New Drugs, 16(16): 1237-1242. [李明华, 张高红, 孙涛, 郑永唐. 2007a. 灵长类动物模型在抗HIV药物研究中的应用. 中国新药杂志, 16(16): 1237-1242.]
    [48] Li MH, Li SY, Xia HJ, Wang L, Wang YY, Zhang GH, Zheng YT. 2007b. Establishment of AIDS animal model with SIVmac239 infected Chinese rhesus monkey. Virologica Sinica, 22(6): 509-516.
    [49] Li PL, Chen QQ, Zhang CY. 2012. SAMHD1—A HIV-1 restriction factor derived from Myeloid lineage monocytes. Zoological Research, 33(5): 537-541. [李佩璐, 陈倩倩, 张弛宇. 2012a. 髓系单核细胞来源的HIV-1限制因子—SAMHD1. 动物学研究, 33(5): 537-541.]
    [50] Li SY, Xia HJ, Dai ZX, Zhang GH, Fan B, Li MH, Wang RR, Zheng YT. 2012. Dynamics and functions of CD4+CD25high regulatory T lymphocytes in Chinese rhesus macaques during the early stage of infection with SIVmac239. Archives of Virology, 157(5): 961-967.
    [51] Liao CH, Kuang YQ, Liu HL, Zheng YT, Su B. 2007. A novel fusion gene, TRIM5-Cyclophilin A in the pig-tailed macaque determines its susceptibility to HIV-1 infection. AIDS, 21(Suppl 8): S19-S26.
    [52] Looney DJ, McClure J, Kent SJ, Radaelli A, Kraus G, Schmidt A, Steffy K, Greenberg P, Hu SL, Morton WR, Wong-Staal F. 1998. A minimally replicative HIV-2 live-virus vaccine protects M. nemestrina from disease after HIV-2(287) challenge. Virology, 242(1): 150-160.
    [53] Ma JP, Xia HJ, Zhang GH, Han JB, Zhang LG, Zheng YT. 2012. Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239 infected Chinese rhesus macaques. Cellular and Molecular Immunology, 9(5): 410-416.
    [54] Mason RD, de Rose R, Seddiki N, Kelleher AD, Kent SJ. 2008. Low pre-infection levels and loss of central memory CD4+ T cells may predict rapid progression in SIV-infected pigtail macaques. Virology, 381(1): 11-15.
    [55] Morales JC, Melnick DJ. 1998. Phylogenetic relationships of the macaques (Cercopithecidae: Macaca), as revealed by high resolution restriction site mapping of mitochondrial ribosomal genes. Journal of Human Evoloution, 34(1): 1-23.
    [56] Mussil B, Sauermann U, Motzkus D, Stahl-Hennig C, Sopper S. 2011. Increased APOBEC3G and APOBEC3F expression is associated with low viral load and prolonged survival in simian immunodeficiency virus infected rhesus monkeys. Retrovirology, 8(1): 77.
    [57] Nomaguchi M, Yokoyama M, Kono K, Nakayama EE, Shioda T, Saito A, Akari H, Yasutomi Y, Matano T, Sato H, Adachi A. 2013. Gag-CA Q110D mutation elicits TRIM5-independent enhancement of HIV-1mt replication in macaque cells. Microbes and Infection, 15(1): 56-65.
    [58] O'Neil SP, Mossman SP, Maul DH, Hoover EA. 1999. Virus threshold determines disease in SIVsmmPBj14-infected macaques. AIDS Research and Human Retroviruses, 15(2): 183-194.
    [59] Pang W, Lv LB, Wang Y, Li C, Huang DT, Lei AH, Zhang GH, Zheng YT. 2013, Measurement and analysis of hematology and blood chemistry parameters in northern pigtailed macaques (Macaca leonina). Zoological Research, 34(2): 89-96. [庞伟,吕龙宝,王芸,李贵,黄东体,雷爱华,张高红,郑永唐. 北平顶猴 (Macaca leonina) 血液学和血液生化指标参考值的测定与分析. 动物学研究, 2013, 34(2): 89-96.]
    [60] Patton DL, Sweeney YT, Paul KJ. 2009. A summary of preclinical topical microbicide rectal safety and efficacy evaluations in a pigtailed macaque model. Sexually Transmitted Diseases, 36(6): 350-356.
    [61] Patton DL, Cosgrove-Sweeney YT, Rabe LK, Hillier SL. 2001. The pig-tailed macaque rectal model: microflora and chlamydial infection. Sexually Transmitted Diseases, 28(7): 363-366.
    [62] Patton DL, Sweeney YC, Tsai CC, Hillier SL. 2004. Macaca fascicularis vs. Macaca nemestrina as a model for topical microbicide safety studies. Journal of Medical Primatology, 33(2): 105-108.
    [63] Patton DL, Sweeney YT, Agnew KJ, Balkus JE, Rabe LK, Hillier SL. 2006. Development of a nonhuman primate model for Trichomonas vaginalis infection. Sexually Transmitted Diseases, 33(12): 743-746.
    [64] Polacino P, Larsen K, Galmin L, Suschak J, Kraft Z, Stamatatos L, Anderson D, Barnett SW, Pal R, Bost K, Bandivdekar AH, Miller CJ, Hu SL. 2008. Differential pathogenicity of SHIV infection in pig-tailed and rhesus macaques. Journal of Medical Primatology, 37(Suppl 2): 13-23.
    [65] Pullium JK, Adams DR, Jackson E, Kim CN, Smith DK, Janssen R, Gould K, Folks TM, Butera S, Otten RA. 2001. Pig-tailed macaques infected with human immunodeficiency virus (HIV) type 2GB122 or simian/HIV89. 6p express virus in semen during primary infection: new model for genital tract shedding and transmission. Journal of Infectious Diseases, 183(7): 1023-1030.
    [66] Rosenblum LL, Supriatna J, Melnick DJ. 1997. Phylogeographic analysis of pigtail macaque populations (Macaca nemestrina) inferred from mitochondrial DNA. American Journal of Physical Anthropology, 104(1): 35-45.
    [67] Saito A, Nomaguchi M, Iijima S, Kuroishi A, Yoshida T, Lee YJ, Hayakawa T, Kono K, Nakayama EE, Shioda T, Yasutomi Y, Adachi A, Matano T, Akari H. 2011. Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications. Microbes and Infection, 13(1): 58-64.
    [68] Shehu-Xhilaga M, Kent S, Batten J, Ellis S, Van der Meulen J, O'Bryan M, Cameron PU, Lewin SR, Hedger MP. 2007. The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infection. Retrovirology, 4(1): 7.
    [69] Shibata R, Kawamura M, Sakai H, Hayami M, Ishimoto A, Adachi A. 1991. Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells. Journal of Virology, 65(7): 3514-3520.
    [70] Smith MZ, Dale CJ, de Rose R, Stratov I, Fernandez CS, Brooks AG, Weinfurter J, Krebs K, Riek C, Watkins DI, O'Connor DH, Kent SJ. 2005. Analysis of pigtail macaque major histocompatibility complex class I molecules presenting immunodominant simian immunodeficiency virus epitopes. Journal of Virology, 79(2): 684-695.
    [71] Spear GT, Kersh E, Guenthner P, Vishwanathan SA, Gilbert D, Zariffard MR, Mirmonsef P, Landay A, Zheng L, Gillevet P. 2012. Longitudinal assessment of pigtailed macaque lower genital tract microbiota by pyrosequencing reveals dissimilarity to the genital microbiota of healthy humans. AIDS Research and Human Retroviruses, 28(10): 1244-1249.
    [72] Staprans SI, Feinberg MB. 2004. The roles of nonhuman primates in the preclinical evaluation of candidate AIDS vaccines. Expert Review of Vaccines, 3(4 Suppl): S5-S32.
    [73] Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J. 2004. The cytoplasmic body component TRIM5 alpha restricts HIV-1 infection in Old World monkeys. Nature, 427(6977): 848-853.
    [74] Thippeshappa R, Polacino P, Yu Kimata MT, Siwak EB, Anderson D, Wang W, Sherwood L, Arora R, Wen M, Zhou P, Hu SL, Kimata JT. 2011. Vif substitution enables persistent infection of pig-tailed macaques by human immunodeficiency virus type 1. Journal of Virology, 85(8): 3767-3779.
    [75] Uberla K, Stahl-Hennig C, Bottiger D, Matz-Rensing K, Kaup FJ, Li J, Haseltine WA, Fleckenstein B, Hunsmann G, Oberg B. 1995. Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 92(18): 8210-8214.
    [76] Ulenga NK, Sarr AD, Thakore-Meloni S, Sankale JL, Eisen G, Kanki PJ. 2008. Relationship between human immunodeficiency type 1 infection and expression of human APOBEC3G and APOBEC3F. The Journal of Infectious Diseases, 198(4): 486-492.
    [77] Van Rompay KK. 2012. The use of nonhuman primate models of HIV infection for the evaluation of antiviral strategies. AIDS Research and Human Retroviruses, 28(1): 16-35.
    [78] Vishwanathan SA, Guenthner PC, Lin CY, Dobard C, Sharma S, Adams DR, Otten RA, Heneine W, Hendry RM, McNicholl JM, Kersh EN. 2011. High susceptibility to repeated, low-dose, vaginal SHIV exposure late in the luteal phase of the menstrual cycle of pigtail macaques. Journal of Acquired Immune Deficiency Syndromes, 57(4): 261-264.
    [79] Xia HJ, Ma JP, Zhang GH, Han JB, Wang JH, Zheng YT. 2011. Effect of plasma viremia on apoptosis and immunophenotype of dendritic cells subsets in acute SIVmac239 infection of Chinese rhesus macaques. PLoS One, 6(12): e29036.
    [80] Xia HJ, Zhang GH, Ma JP, Dai ZX, Li SY, Han JB, Zheng YT. 2010. Dendritic cell subsets dynamics and cytokine productions in SIVmac239 infected Chinese rhesus macaques. Retrovirology, 7(1): 102.
    [81] Zhang GH, Li MH, Zheng YT. 2007. Application of AIDS macaques animal model in HIV vaccine research. Zoological Research, 28(5): 556-562. [张高红, 李明华, 郑永唐. 2007. AIDS 猕猴模型在HIV疫苗研究中的应用. 动物学研究, 28(5): 556-562.]
    [82] Zhou DY, Zhang X, Li WH, Xu XN, Goonetilleke N, Yang HB, Dong T, Yan HP. 2013. Broader T cell responses directed against human immunodeficiency virus type 1 in infected Chinese individuals through blood-borne transmission in comparison with mucosal transmission. AIDS Research and Human Retroviruses, 29(1): 89-93.
    [83] Zhu L, Zhang GH, Zheng YT. 2010. Application studies of animal models in evaluating safety and efficacy of HIV-1 microbicides. Zoological Research, 31(1): 66-76. [朱林, 张高红, 郑永唐. 2010. 动物模型在HIV-1杀微生物剂有效性和安全性评价中的应用. 动物学研究, 31(1): 66-76.]
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出版历程
  • 收稿日期:  2012-11-27
  • 修回日期:  2013-01-07
  • 刊出日期:  2013-04-08

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