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Aging affects early stage direction selectivity of MT cells in rhesus monkeys

LIANG Zhen CHEN Yue-Ming MENG Xue WANG Yi ZHOU Bao-Zhuo XIE Ying-Ying HE Wen-Sheng

LIANG Zhen, CHEN Yue-Ming, MENG Xue, WANG Yi, ZHOU Bao-Zhuo, XIE Ying-Ying, HE Wen-Sheng. Aging affects early stage direction selectivity of MT cells in rhesus monkeys. Zoological Research, 2012, 33(5): 498-502. doi: 10.3724/SP.J.1141.2012.05498
Citation: LIANG Zhen, CHEN Yue-Ming, MENG Xue, WANG Yi, ZHOU Bao-Zhuo, XIE Ying-Ying, HE Wen-Sheng. Aging affects early stage direction selectivity of MT cells in rhesus monkeys. Zoological Research, 2012, 33(5): 498-502. doi: 10.3724/SP.J.1141.2012.05498

老化对猕猴中颞视区细胞早期方向选择性的影响

doi: 10.3724/SP.J.1141.2012.05498
基金项目: 国家自然科学基金面上项目(31171082); 安徽省高等学校省级自然科学研究项目(KJ2012A154)
详细信息
  • 中图分类号: Q436; Q429+2; Q421; Q424

Aging affects early stage direction selectivity of MT cells in rhesus monkeys

  • 摘要: 中颞视区(middle temporal area、MT/V5)在视觉运动处理过程中起着重要作用。MT区神经元对物体运动方向具有强选择性, 而这种细胞的方向选择性被认为是运动方向知觉的神经基础, 且已有实验表明方向选择性由于受到注意影响,而在时间进程上分为2个阶段。该研究组先前的实验发现麻醉猕猴 (Rhesus macaque) MT区细胞的方向选择性发生了衰退, 但该衰退是整个时间进程上平均的结果, 并不能在时间进程上揭示其神经机制。因此, 为了进一步探索运动方向感知能力下降的神经机制, 该实验采用单细胞技术在麻醉猕猴的MT区研究了在正常老化过程中MT区细胞的早期方向选择性变化(early stage direction selectivity, esDB), 结果表明老年猕猴MT区细胞早期方向选择性显著降低, 具有强早期方向选择性的细胞显著减少。该结果进一步揭示了MT区细胞方向选择性在早期发生的衰退可能介导了视觉运动感知能力的下降。
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出版历程
  • 收稿日期:  2012-06-11
  • 修回日期:  2012-07-10
  • 刊出日期:  2012-10-10

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