两种不同训练时程方法对海马损伤大鼠水迷宫成绩的影响

BIAN Hui; FANG Song; MIAO Ying-Da; YU Hua-Lin

doi:10.3724/SP.J.1141.2012.02237

两种不同训练时程方法对海马损伤大鼠水迷宫成绩的影响

doi: 10.3724/SP.J.1141.2012.02237

1.
昆明医学院云南昆明 650032;
2.
南昌大学第一附属医院医务科江西南昌 330006;
3.
中国人民银行昆明市中心支行云南昆明 650223

基金项目: “973”计划 (2007CB947703)

详细信息

中图分类号: R338; Q42
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- 被引次数: 0
出版历程
- 收稿日期: 2011-08-09
- 修回日期: 2011-11-20
- 刊出日期: 2012-04-22

Influences of two different training paradigms on spatial learning and memory performance of hippocampal injured rats

1.
Kunming Medical College, Kunming 650032, China;
2.
Medical Department, First Affiliated Hospital of Jiangxi Medical University, Nanchang 330006, China;
3.
Kunming Branch, People’s Bank of China, Kunming 650223, China

摘要

摘要: 为探讨训练时程对大鼠水迷宫成绩的影响,采用直流电解法建立双侧背侧海马损伤大鼠模型,并通过5 d(5 d training)和7 d训练(7 d training)两种不同时程法检测海马损伤大鼠的空间学习记忆能力。结果表明,两种训练法均反映大鼠空间学习能力减退,而在检测空间记忆障碍时则略有不同。与5 d训练法相比,7 d训练法不仅显示大鼠穿台次数下降,且其在目标象限中的停留时间百分比亦下降。
- 水迷宫 /
- 空间学习记忆 /
- 海马损伤
Abstract: In this study, the 5 d and 7 d training paradigms were adopted to investigate the influences of different training procedures on the performance of spatial learning and memory of the hippocampal injured rats. The results showed that during the hidden-platform acquisition training, similar spatial learning dysfunctions were indicated in those two training paradigms. Whereas, when the spatial memories have been evaluated, compared with the 5 d training groups,the rats under 7 d training procedure not only crossed the platform location less, but also preferred to spend less time in the target quadrant.
- Morris water maze /
- Spatial learning and memory /
- Hippocampal injury

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参考文献(13)

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