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Effects of odor cue on morphine-induced dependence and craving in mice

LIU Xiao-Fen YANG Guang YANG Rui JIA Qiang GUAN Su-Dong

LIU Xiao-Fen, YANG Guang, YANG Rui, JIA Qiang, GUAN Su-Dong. Effects of odor cue on morphine-induced dependence and craving in mice. Zoological Research, 2012, (2): 165-169. doi: 10.3724/SP.J.1141.2012.02165
Citation: LIU Xiao-Fen, YANG Guang, YANG Rui, JIA Qiang, GUAN Su-Dong. Effects of odor cue on morphine-induced dependence and craving in mice. Zoological Research, 2012, (2): 165-169. doi: 10.3724/SP.J.1141.2012.02165

气味线索对小鼠形成吗啡依赖及渴求的影响

doi: 10.3724/SP.J.1141.2012.02165
基金项目: 安徽省高校优秀青年人才基金项目(2011SQRL083ZD)
详细信息
  • 中图分类号: Q434; R338.2; R992; R996

Effects of odor cue on morphine-induced dependence and craving in mice

  • 摘要: 利用条件化位置偏好模型研究气味线索对吗啡依赖及渴求的影响,其结果发现,单一嗅觉条件刺激使小鼠建立条件化位置偏好,形成吗啡依赖。当改变外界环境,动物进入完全新异的环境后依然寻求与吗啡相关的气味线索,说明吗啡相关气味条件线索诱发了小鼠对吗啡的渴求。多巴胺D1或D2受体拮抗剂能阻断小鼠对气味线索的寻求。该结果表明嗅觉系统在药物成瘾过程中具有一定作用。
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出版历程
  • 收稿日期:  2011-10-08
  • 修回日期:  2011-10-24
  • 刊出日期:  2012-04-22

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