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Reproductive traits of polycystic ovary syndrome in female rhesus monkeys

TANG Xiang-Hui CAO Yue-Ling YANG Ze-Xing ZHAO Fu-Xian

TANG Xiang-Hui, CAO Yue-Ling, YANG Ze-Xing, ZHAO Fu-Xian. Reproductive traits of polycystic ovary syndrome in female rhesus monkeys. Zoological Research, 2012, 33(1): 37-42. doi: 10.3724/SP.J.1141.2012.01037
Citation: TANG Xiang-Hui, CAO Yue-Ling, YANG Ze-Xing, ZHAO Fu-Xian. Reproductive traits of polycystic ovary syndrome in female rhesus monkeys. Zoological Research, 2012, 33(1): 37-42. doi: 10.3724/SP.J.1141.2012.01037

多囊卵巢综合征猕猴的生殖特性

doi: 10.3724/SP.J.1141.2012.01037
基金项目: This work was supported by Yunnan Key Laboratory of Animal Reproductive Biology(2010-03)
详细信息
  • 中图分类号: Q418; Q492.5; Q954.592

Reproductive traits of polycystic ovary syndrome in female rhesus monkeys

Funds: This work was supported by Yunnan Key Laboratory of Animal Reproductive Biology(2010-03)
  • 摘要: 多囊卵巢综合征(PCOS)是临床上常见的一种内分泌失调性疾病,也是造成无排卵性不孕的重要原因。对多囊卵巢综合征动物模型的研究有10 余年,迄今尚未建立起较为理想的模型动物。该研究的目的在于构建猕猴多囊卵巢综合征动物模型,并分析该模型动物的一些主要生殖特性。将6 只成年雌性猕猴(6~10 a)平均分成2 组:PCOS 模型组和对照组。模型组动物的建立方法是:在月经周期的第1、3、5 天,分别皮下注射丙酸睾丸酮一次,剂量为3.5 mg/kg 体重;接着在第7、9、11 天,分别肌注人绒毛膜促性腺激素一次,剂量是350IU/kg 体重;连续注射2 个月经周期。对照组动物注射生理盐水。结果显示:PCOS 模型组动物呈现出高血清LH和T,分别为(5.35±0.17) IU/L 和(7.58±0.14) ng/mL,而且血清LH/FSH 值(5.35/1.30=4.12);模型组动物血清FSH、 E2 和P 的含量与对照组无显著差异。腹部B 超扫描结果提示,模型组动物卵巢多囊化。对两组动物进行超排处理后,模型组动物卵巢呈明显的过刺激现象,模型组动物胚胎体外培养的囊胚率为23.53%,显著低于对照组(66.67%)(P<0.05),即用丙酸睾丸酮联合人绒毛膜促性腺激素,能够建立PCOS 猕猴模型,该模型动物的一些主要生殖特性与人类PCOS 相似。
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  • 收稿日期:  2011-10-24
  • 修回日期:  2011-12-10
  • 刊出日期:  2012-02-22

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