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Sleep disorder, a potential early diagnostic marker for psychiatric and neurodegenerative diseases

CHEN Yan-Mei QIN Dong-Dong JIANG Hui-Hui HU Xin-Tian MA Yuan-Ye

CHEN Yan-Mei, QIN Dong-Dong, JIANG Hui-Hui, HU Xin-Tian, MA Yuan-Ye. Sleep disorder, a potential early diagnostic marker for psychiatric and neurodegenerative diseases. Zoological Research, 2011, 32(1): 81-90. doi: 10.3724/SP.J.1141.2011.01081
Citation: CHEN Yan-Mei, QIN Dong-Dong, JIANG Hui-Hui, HU Xin-Tian, MA Yuan-Ye. Sleep disorder, a potential early diagnostic marker for psychiatric and neurodegenerative diseases. Zoological Research, 2011, 32(1): 81-90. doi: 10.3724/SP.J.1141.2011.01081

非人灵长类动物模型睡眠研究在神经精神疾病的早期诊断和药效评价中的作用

doi: 10.3724/SP.J.1141.2011.01081
基金项目: 中国科学院知识创新工程重要方向项目(KSCX2-EW-R-11);中国科学院基础前沿研究专项项目(KSCX2-EW-J-23)资助
详细信息
    作者简介:

    陈艳梅, 女, 中国科学院昆明动物研究所08级博士, 专业方向为神经生物学, E-mail:chyanm2@126.com

    通讯作者:

    胡新天,马原野

  • 中图分类号: R-332;R749; R338.64; Q 959.848

Sleep disorder, a potential early diagnostic marker for psychiatric and neurodegenerative diseases

More Information
    Author Bio:

    CHEN Yan-Mei,E-mail:chyanm2@126.com

    Corresponding author: HU Xin-Tian,MA Yuan-Ye
  • 摘要: 清醒−睡眠的周期性调节需要众多单胺类神经递质(5-HT、NE、DA等)、乙酰胆碱等兴奋性神经递质以及GABA等抑制性神经递质的参与。这些递质系统的异常不仅会导致睡眠周期紊乱, 还与一系列的精神性和神经退行性疾病相关。睡眠异常被认为是抑郁症、帕金森氏病等神经系统疾病发生的早期预警信号。相比起低等哺乳动物, 非人灵长类动物的睡眠与人类的睡眠具有更好的可比性。近来, 利用非人灵长类动物来建立神经精神疾病模型的研究已取得明显进展。在建模的同时监测动物的睡眠状况, 有助于我们进一步了解睡眠在这些疾病早期诊断和发展过程中的作用, 为疾病的早期诊断、治疗和药效评价提供更好的客观依据。
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  • 收稿日期:  2010-12-15
  • 修回日期:  2011-01-06
  • 刊出日期:  2011-02-22

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