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Association of the schizophrenia susceptible gene DKK4 with brain volume in Chinese populations

ZHANG Li-Hua LI Ming SHI Xiao-Dong REN Hui SU Bing XU Zhong

ZHANG Li-Hua, LI Ming, SHI Xiao-Dong, REN Hui, SU Bing, XU Zhong. Association of the schizophrenia susceptible gene DKK4 with brain volume in Chinese populations. Zoological Research, 2011, 32(1): 62-65. doi: 10.3724/SP.J.1141.2011.01062
Citation: ZHANG Li-Hua, LI Ming, SHI Xiao-Dong, REN Hui, SU Bing, XU Zhong. Association of the schizophrenia susceptible gene DKK4 with brain volume in Chinese populations. Zoological Research, 2011, 32(1): 62-65. doi: 10.3724/SP.J.1141.2011.01062

精神分裂症易感基因DKK4与中国人群大脑容量的相关性

doi: 10.3724/SP.J.1141.2011.01062
详细信息
    通讯作者:

    宿 兵,徐 忠

  • 中图分类号: Q987.2; Q593.2; R749.3

Association of the schizophrenia susceptible gene DKK4 with brain volume in Chinese populations

More Information
    Corresponding author: SU Bing,XU Zhong
  • 摘要: 精神分裂症是一种复杂的精神疾病, 全世界约有1%的人患有这种疾病。以往的研究发现, 精神分裂症患者的脑容量比正常人小, 且一些精神分裂症易感基因的DNA序列多态性也同时与脑的结构异常有关, 这与精神分裂症的神经发育假说是吻合的。最近研究发现, 人的DKK4基因的SNP(rs2073665)与精神分裂症显著相关。为了研究DKK4精神分裂症易感SNP是否与脑发育相关, 本文检测了961个正常人rs2073665的基因型并测量了他们的脑容量。相关性分析发现, rs2073665在加性模型下和显性模型下都与脑容量存在显著相关性, 这为精神分裂症易感基因同时能影响脑容量提供了证据, 同时也为精神分裂症的神经发育异常假说提供了佐证。
  • [1] Cahn W, Hulshoff Pol HE, Lems EB, van Haren NE, Schnack HG, van der Linden JA, Schothorst PF, van Engeland H, Kahn RS. 2002. Brain volume changes in first-episode schizophrenia: A 1-year follow-up study [J]. Arch Gen Psychiatry, 59(11): 1002-1010.Clevers H .2006. Wnt/beta-catenin signaling in development and disease [J]. Cell, 127(3): 469-480.Fuerer C, Nusse R, Ten Berge D. 2008. Wnt signalling in development and disease. Max Delbruck Center for Molecular Medicine meeting on Wnt signaling in Development and Disease [J]. EMBO Rep, 9(2): 134-138.Ho BC, Andreasen NC, Dawson JD, Wassink TH. 2007. Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia [J]. Am J Psychiatry, 164(12): 1890-1899.Ho BC, Wassink TH, O'Leary DS, Sheffield VC, Andreasen NC. 2005. Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: Working memory, frontal lobe MRI morphology and frontal cerebral blood flow [J]. Mol Psychiatry, 10(3): 229, 287-298.Ho KC, Roessmann U, Straumfjord JV, Monroe G. 1980. Analysis of brain weight. II. Adult brain weight in relation to body height, weight, and surface area[J]. Arch Pathol Lab Med, 104(12): 640-645.Honea R, Crow TJ, Passingham D, Mackay CE. 2005. Regional deficits in brain volume in schizophrenia: A meta-analysis of voxel-based morphometry studies[J]. Am J Psychiatry, 162(12): 2233-2245.Jablensky A, Sartorius N, Korten A, Ernberg G, Anker M, Cooper JE,Day R. 1987. Incidence worldwide of schizophrenia [J]. Br J Psychiatry, 151: 408-409.Lang UE, Puls I, Muller DJ, Strutz-Seebohm N, Gallinat J. 2007. Molecular mechanisms of schizophrenia[J]. Cell Physiol Biochem,20(6): 687-702.Lawrie SM, Abukmeil SS 1998. Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies [J]. Br J Psychiatry, 172: 110-120.Logan CY, Nusse R. 2004. The Wnt signaling pathway in development and disease [J]. Annu Rev Cell Dev Biol, 20: 781-810.Mao B, Wu W, Davidson G, Marhold J, Li M, Mechler BM, Delius H, Hoppe D, Stannek P, Walter C, Glinka A, Niehrs C. 2002. Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signaling [J]. Nature, 417(6889): 664-667.Proitsi P, Li T, Hamilton G, Di Forti M, Collier D, Killick R, Chen R, Sham P, Murray R, Powell J, Lovestone S. 2008. Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4 [J]. Biol Psychiatry, 63(1): 13-16.Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC. 2007. PLINK: A tool set for whole-genome association and population-based linkage analyses [J]. Am J Hum Genet, 81(3): 559-575.Rimol LM, Hartberg CB, Nesvåg R, Fennema-Notestine C, Hagler DJ Jr, Pung CJ, Jennings RG, Haukvik UK, Lange E, Nakstad PH, Melle I, Andreassen OA, Dale AM, Agartz I. 2010. Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder [J]. Biol Psychiatry, 68(1): 41-50.Steen RG, Mull C, McClure R, Hamer RM, Lieberman JA. 2006. Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies [J]. Br J Psychiatry, 188: 510-518.Velakoulis D, Pantelis C, McGorry PD, Dudgeon P, Brewer W, Cook M, Desmond P, Bridle N, Tierney P, Murrie V, Singh B, Copolov D. 1999. Hippocampal volume in first-episode psychoses and chronic schizophrenia: a high-resolution magnetic resonance imaging study [J]. Arch Gen Psychiatry, 56(2): 133-141.Yang J, Si T, Ling Y, Ruan Y, Han Y, Wang X, Zhang H, Kong Q, Li X, Liu C, Zhang D, Zhou M, Yu Y, Liu S, Shu L, Ma D, Wei J, Zhang D. 2003. Association study of the human FZD3 locus with schizophrenia [J]. Biol Psychiatry, 54(11): 1298-1301.
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出版历程
  • 收稿日期:  2010-08-17
  • 修回日期:  2010-11-10
  • 刊出日期:  2011-02-22

Association of the schizophrenia susceptible gene DKK4 with brain volume in Chinese populations

doi: 10.3724/SP.J.1141.2011.01062
    通讯作者: SU Bing,XU Zhong
  • 中图分类号: Q987.2; Q593.2; R749.3

摘要: 精神分裂症是一种复杂的精神疾病, 全世界约有1%的人患有这种疾病。以往的研究发现, 精神分裂症患者的脑容量比正常人小, 且一些精神分裂症易感基因的DNA序列多态性也同时与脑的结构异常有关, 这与精神分裂症的神经发育假说是吻合的。最近研究发现, 人的DKK4基因的SNP(rs2073665)与精神分裂症显著相关。为了研究DKK4精神分裂症易感SNP是否与脑发育相关, 本文检测了961个正常人rs2073665的基因型并测量了他们的脑容量。相关性分析发现, rs2073665在加性模型下和显性模型下都与脑容量存在显著相关性, 这为精神分裂症易感基因同时能影响脑容量提供了证据, 同时也为精神分裂症的神经发育异常假说提供了佐证。

English Abstract

张丽华, 李 明, 施晓东, 任 惠, 宿 兵, 徐 忠. 精神分裂症易感基因DKK4与中国人群大脑容量的相关性[J]. 动物学研究, 2011, 32(1): 62-65. doi: 10.3724/SP.J.1141.2011.01062
引用本文: 张丽华, 李 明, 施晓东, 任 惠, 宿 兵, 徐 忠. 精神分裂症易感基因DKK4与中国人群大脑容量的相关性[J]. 动物学研究, 2011, 32(1): 62-65. doi: 10.3724/SP.J.1141.2011.01062
ZHANG Li-Hua, LI Ming, SHI Xiao-Dong, REN Hui, SU Bing, XU Zhong. Association of the schizophrenia susceptible gene DKK4 with brain volume in Chinese populations. Zoological Research, 2011, 32(1): 62-65. doi: 10.3724/SP.J.1141.2011.01062
Citation: ZHANG Li-Hua, LI Ming, SHI Xiao-Dong, REN Hui, SU Bing, XU Zhong. Association of the schizophrenia susceptible gene DKK4 with brain volume in Chinese populations. Zoological Research, 2011, 32(1): 62-65. doi: 10.3724/SP.J.1141.2011.01062
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