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Tree shrew models: A chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory

WANG Jing ZHOU Qi-Xin TIAN Men YANG Yue-Xiong XU Lin

WANG Jing, ZHOU Qi-Xin, TIAN Men, YANG Yue-Xiong, XU Lin. Tree shrew models: A chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory. Zoological Research, 2011, 32(1): 24-30. doi: 10.3724/SP.J.1141.2011.01024
Citation: WANG Jing, ZHOU Qi-Xin, TIAN Men, YANG Yue-Xiong, XU Lin. Tree shrew models: A chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory. Zoological Research, 2011, 32(1): 24-30. doi: 10.3724/SP.J.1141.2011.01024

树鼩模型:抑郁症的社会竞争失败与学习和记忆的被捕获条件反射(英文)

doi: 10.3724/SP.J.1141.2011.01024
详细信息
    作者简介:

    王 静

    通讯作者:

    徐 林

  • 中图分类号: Q175; Q133

Tree shrew models: A chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory

Funds: This work was supported by grants KSCX2-EW-R-12 and KSCX2-EW-J-23 from the Chinese Academy of Sciences
More Information
    Author Bio:

    WANG Jing

    Corresponding author: XU Lin
  • 摘要: 最近基因组研究表明树鼩属于灵长类或是与灵长类亲缘关系最密切的姐妹种。因此, 树鼩可能是应用于建立人类疾病动物模型的最佳动物之一。该文报道一种抑郁症的社会竞争失败病因学树鼩 (Tupaia belangeri chinensis)模型。一对雄性树鼩被饲养在一个双笼中, 用网格把双笼隔开, 网格上有一小门。适应1周后, 把小门打开, 这一对树鼩产生短暂的争斗, 每天一次,连续21天。其中争斗失败者被称为服从者。这个过程可导致每天1 h的直接社交冲突和23 h的间接相互影响 (比如通过气味、视觉等)。与正常对照相比, 失败者在第三周也就是社交冲突的最后一周显示了体重、自主活动、躲避行为、尿液皮质醇水平等的变化, 并且这种改变可持续至少2周以上。此外, 还报道全新的记忆模型, 一种被捕获条件反射树鼩模型。在一个封闭的小房间中放置捕获笼, 其中挂有一片苹果, 小房间中有一只自由活动的树鼩。训练的前4次树鼩进入捕获笼吃苹果并不触发捕获笼关闭, 但在第5次时触发捕获笼关闭, 并持续一小时才释放树鼩。第1—5次树鼩进入捕获笼的延迟时间作为适应性指标, 其中第5次才是作为被捕获的一次学习训练。24 h后, 测试树鼩进入捕获笼的延迟时间作为被捕获记忆能力指标。树鼩经过第5次被捕获训练, 能形成很好的被捕获记忆, 因为24 h后的延迟时间极大地增加。在训练前腹腔注射已知能阻断记忆形成的NMDA受体拮抗剂MK-801 (0.2 mg/kg, 腹腔注射), 对适应指标没有显著影响, 但是极大地缩短了24 h后测试的延迟时间, 即阻断了被捕获记忆。这些结果表明了一种抑郁症的慢性社会竞争失败与学习和记忆的一次被捕获条件反射树鼩模型。这两种树鼩模型对抑郁症与学习和记忆的机理研究、抗抑郁症新药的临床前药效学评价具有潜在的重要意义。
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    [J]. Pharmacol Biochem Behav, 73(1): 247-258.Fuchs E, Kramer M, Hermes B, Netter P, Hiemke C. 1996. Psychosocial stress in tree shrews: Clomipramine counteracts behavioral and endocrine changes [J]. Pharmacol Biochem Behav, 54(1): 219-228.Helgen, Kristofer M, Wilson, Don E, Reeder, DeeAnn M. 2005. Mammal Species of the World (3rd ed.) [M]. Baltimore: Johns Hopkins University Press, 104-109.Holst D. 1977. Social stress in tree-shrews: Problems, results, and goals [J]. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 120(1): 71-86.Janecka JE, Miller W, Pringle TH, Wiens F, Zitzmann A, Helgen KM, Springer MS, Murphy WJ. 2007. Molecular and genomic data identify the closest living relatives of primates [J]. Science, 318 (5851): 792-794.Kovacic P, Somanathan R. 2010. Clinical physiology and mechanism of dizocilpine (MK-801) Electron transfer, radicals, redox metabolites and bioactivity [J]. Oxid Med Cell Longev, 3(1): 13-22.Kozicz TBordewin LACzéh BFuchs ERoubos EW. 2008. Chronic psychosocial stress affects corticotropin-releasing factor in the paraventricular nucleus and central extended amygdala as well as urocortin in the non-preganglionic Edinger-Westphal nucleus of the tree shrew [J]. Psychoneuroendocrinology, 33(6): 741-754.Magariños AM, McEwen BS, Flügge G, Fuchs E. 1996. Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews [J]. J Neurosci, 16(10): 3534-3540. Meyer Uvan Kampen MIsovich EFlügge GFuchs E. 2001. Chronic psychosocial stress regulates the expression of both GR and MR mRNA in the hippocampal formation of tree shrews [J]. Hippocampus, 11(3): 329-336.Ohl FOitzl MSFuchs E. 1998. Assessing cognitive functions in tree shrews: Visual-spatial and spatial learning in the home cage [J]. J Neurosci Methods, 81(1-2): 35-40.Takahashi M, Ushitani T, Fujita K. 2008. Inference based on transitive relation in tree shrews (Tupaia belangeri) and rats (Rattus norvegicus) on a spatial discrimination task [J]. Psychol Rec, 58(2): 215-227.Vales K, Bubenikova-Valesova V, Klement DStuchlik A. 2006. Analysis of sensitivity to MK-801 treatment in a novel active allothetic place avoidance task and in the working memory version of the Morris water maze reveals differences between Long-Evans and Wistar rats
    [J]. Neurosci Res, 55(4): 383-388.van der Hart MG, de Biurrun G, Czéh B, Rupniak NM, den Boer JA, Fuchs E. 2005. Chronic psychosocial stress in tree shrews: Effect of the substance P (NK1 receptor) antagonist L-760735 and clomipramine on endocrine and behavioral parameters [J]. Psychopharmacology (Berl), 181(2): 207-216.van Kampen M, Schmitt U, Hiemke C, Fuchs E. 2000. Diazepam has no beneficial effects on stress-induced behavioural and endocrine changes in male tree shrews [J]. Pharmacol Biochem Behav, 65(3): 539-546.
    [4]
     
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出版历程
  • 收稿日期:  2010-12-01
  • 修回日期:  2010-12-22
  • 刊出日期:  2011-02-22

Tree shrew models: A chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory

doi: 10.3724/SP.J.1141.2011.01024
    基金项目:  This work was supported by grants KSCX2-EW-R-12 and KSCX2-EW-J-23 from the Chinese Academy of Sciences
    作者简介:

    WANG Jing

    通讯作者: XU Lin
  • 中图分类号: Q175; Q133

摘要: 最近基因组研究表明树鼩属于灵长类或是与灵长类亲缘关系最密切的姐妹种。因此, 树鼩可能是应用于建立人类疾病动物模型的最佳动物之一。该文报道一种抑郁症的社会竞争失败病因学树鼩 (Tupaia belangeri chinensis)模型。一对雄性树鼩被饲养在一个双笼中, 用网格把双笼隔开, 网格上有一小门。适应1周后, 把小门打开, 这一对树鼩产生短暂的争斗, 每天一次,连续21天。其中争斗失败者被称为服从者。这个过程可导致每天1 h的直接社交冲突和23 h的间接相互影响 (比如通过气味、视觉等)。与正常对照相比, 失败者在第三周也就是社交冲突的最后一周显示了体重、自主活动、躲避行为、尿液皮质醇水平等的变化, 并且这种改变可持续至少2周以上。此外, 还报道全新的记忆模型, 一种被捕获条件反射树鼩模型。在一个封闭的小房间中放置捕获笼, 其中挂有一片苹果, 小房间中有一只自由活动的树鼩。训练的前4次树鼩进入捕获笼吃苹果并不触发捕获笼关闭, 但在第5次时触发捕获笼关闭, 并持续一小时才释放树鼩。第1—5次树鼩进入捕获笼的延迟时间作为适应性指标, 其中第5次才是作为被捕获的一次学习训练。24 h后, 测试树鼩进入捕获笼的延迟时间作为被捕获记忆能力指标。树鼩经过第5次被捕获训练, 能形成很好的被捕获记忆, 因为24 h后的延迟时间极大地增加。在训练前腹腔注射已知能阻断记忆形成的NMDA受体拮抗剂MK-801 (0.2 mg/kg, 腹腔注射), 对适应指标没有显著影响, 但是极大地缩短了24 h后测试的延迟时间, 即阻断了被捕获记忆。这些结果表明了一种抑郁症的慢性社会竞争失败与学习和记忆的一次被捕获条件反射树鼩模型。这两种树鼩模型对抑郁症与学习和记忆的机理研究、抗抑郁症新药的临床前药效学评价具有潜在的重要意义。

English Abstract

王静, 周启心, 田 孟, 杨跃雄, 徐 林. 树鼩模型:抑郁症的社会竞争失败与学习和记忆的被捕获条件反射(英文)[J]. 动物学研究, 2011, 32(1): 24-30. doi: 10.3724/SP.J.1141.2011.01024
引用本文: 王静, 周启心, 田 孟, 杨跃雄, 徐 林. 树鼩模型:抑郁症的社会竞争失败与学习和记忆的被捕获条件反射(英文)[J]. 动物学研究, 2011, 32(1): 24-30. doi: 10.3724/SP.J.1141.2011.01024
WANG Jing, ZHOU Qi-Xin, TIAN Men, YANG Yue-Xiong, XU Lin. Tree shrew models: A chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory. Zoological Research, 2011, 32(1): 24-30. doi: 10.3724/SP.J.1141.2011.01024
Citation: WANG Jing, ZHOU Qi-Xin, TIAN Men, YANG Yue-Xiong, XU Lin. Tree shrew models: A chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory. Zoological Research, 2011, 32(1): 24-30. doi: 10.3724/SP.J.1141.2011.01024
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