巴氯芬对慢性吗啡依赖后条件化位置偏好和戒断症状的抑制

NIU Hai-chen; SHANG Bin; SUN Ning-lei; LI Ling; GUAN Yi-liang; YU Hua-lin; Ma Yuan

doi:10.3724/SP.J.1141.2008.06621

巴氯芬对慢性吗啡依赖后条件化位置偏好和戒断症状的抑制

doi: 10.3724/SP.J.1141.2008.06621

1.
中国科学院昆明动物研究所灵长类认知实验室，动物模型和人类疾病机理重点实验室，云南昆明 650223；2. 昆明医学院第一附属医院神经外科，云南昆明 650118；3. 成都军区昆明总医院医学影像科，云南昆明 650032；4. 内蒙古自治区公安厅禁毒总队，呼和浩特 010051

详细信息

通讯作者:
余化霖

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出版历程
- 收稿日期: 2008-05-08
- 修回日期: 1900-01-01
- 刊出日期: 2008-12-22

Baclofen Inhibited the Morphine-induced Conditioned Placed Preference and Withdrawal Syndromes

1.
Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China;
2.
Neurosurgery office, the First Affiliated Hospital of Kunming Medical College, Kunming 650118, China; 3. Medical Image Office, Kunming General Hospital of PLA, Kunming 650032, China;4. Narcotics Control Administration of Inner Mongolian Public Security Department, Huhhot 010051, China

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Corresponding author: YU Hua-lin

摘要

摘要: 小鼠连续7天腹腔注射吗啡（40 mg/kg）建立条件化位置偏好模型，连续皮下递增注射吗啡（25、50、75、100、125、150 mg/kg），成瘾后腹腔注射纳络酮（6 mg/kg）诱导戒断症状（跳跃行为）建立戒断模型。腹腔注射GABAB受体激动剂巴氯芬（2 mg/kg）可以有效地抑制吗啡诱导的条件化位置偏好和减轻纳络酮诱导的戒断症状，结果表明GABA系统参与动物成瘾后渴求和戒断过程，激动GABAB受体可以在一定程度上抑制成瘾的心理和生理戒断症状。
- 吗啡 /
- 成瘾 /
- 戒断 /
- 巴氯芬 /
- 条件化位置偏好 /
- GABA受体 /
- 纳络酮 /
- 生理依赖 /
- 心理依赖
Abstract: The mice with a continuous 7-day intraperitoneal injection of morphine was induced the conditioned placed reference (CPP) model and the mice with a continuous 7-day subcutaneous injection of morphine（25, 50, 75, 100, 125, 150 mg/kg）was induced withdrawal model (jump behavior) by naloxone administration(6 mg/kg). The results suggested that the administration of the GABA_B receptor agonist, baclofen, could effectively attenuate the expression of CPP and the nalxone-induced response in the mice. It could be concluded that activating GABA_B receptor can alleviate physical and psychic dependence syndromes to a certian extent .
- Morphine /
- Addiction /
- Withdrawal /
- Baclofen /
- Conditioned placed preference /
- GABA receptor /
- Naloxone /
- Physiological dependence /
- Psychic-dependence

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