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Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress

Xiao-Liang ZHANG Wei PANG Xin-Tian HU Jia-Li LI Yong-Gang YAO Yong-Tang ZHENG

Xiao-Liang ZHANG, Wei PANG, Xin-Tian HU, Jia-Li LI, Yong-Gang YAO, Yong-Tang ZHENG. Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress. Zoological Research, 2014, 35(6): 447-464. doi: 10.13918/j.issn.2095-8137.2014.6.447
Citation: Xiao-Liang ZHANG, Wei PANG, Xin-Tian HU, Jia-Li LI, Yong-Gang YAO, Yong-Tang ZHENG. Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress. Zoological Research, 2014, 35(6): 447-464. doi: 10.13918/j.issn.2095-8137.2014.6.447

Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress

doi: 10.13918/j.issn.2095-8137.2014.6.447
基金项目: This work was supported by the National Natural Science Foundation of China (81172876, 81273251, U1202228, 81471620); the National Special Science Research Program of China (2012CBA01305); the National Science and Technology Major Project (2013ZX10001-002, 2012ZX10001-007) and the Knowledge Innovation Program of CAS (KSCX2-EW-R-13, KJZD-EW-L10-02)
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    通讯作者:

    Yong-Tang ZHENG

Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress

Funds: This work was supported by the National Natural Science Foundation of China (81172876, 81273251, U1202228, 81471620); the National Special Science Research Program of China (2012CBA01305); the National Science and Technology Major Project (2013ZX10001-002, 2012ZX10001-007) and the Knowledge Innovation Program of CAS (KSCX2-EW-R-13, KJZD-EW-L10-02)
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    Corresponding author: Yong-Tang ZHENG
  • 摘要: Non-human primates (NHPs) are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biomedical research. Compared with developed countries in America and Europe, China has relatively rich primate resources and has continually aimed to develop NHPs resources. Currently, China is a leading producer and a major supplier of NHPs on the international market. However, there are some deficiencies in feeding and management that have hampered China's growth in NHP research and materials. Nonetheless, China has recently established a number of primate animal models for human diseases and achieved marked scientific progress on infectious diseases, cardiovascular diseases, endocrine diseases, reproductive diseases, neurological diseases, and ophthalmic diseases, etc. Advances in these fields via NHP models will undoubtedly further promote the development of China's life sciences and pharmaceutical industry, and enhance China's position as a leader in NHP research. This review covers the current status of NHPs in China and other areas, highlighting the latest developments in disease models using NHPs, as well as outlining basic problems and proposing effective countermeasures to better utilize NHP resources and further foster NHP research in China.
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  • 收稿日期:  2014-06-11
  • 修回日期:  2014-08-15
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