Volume 36 Issue 2
Mar.  2015
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Bo ZHAN, Hong-Yuan MA, Jian-Li WANG, Chao-Bao LIU. Sex differences in morphine-induced behavioral sensitization and social behaviors in ICR mice. Zoological Research, 2015, 36(2): 103-108.
Citation: Bo ZHAN, Hong-Yuan MA, Jian-Li WANG, Chao-Bao LIU. Sex differences in morphine-induced behavioral sensitization and social behaviors in ICR mice. Zoological Research, 2015, 36(2): 103-108.

Sex differences in morphine-induced behavioral sensitization and social behaviors in ICR mice

Funds:  This study was supported by the National Natural Science Foundation of China (31260513); the National Innovation Experiment Program for University Students (XJCX-2014-106)
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  • Corresponding author: Jian-Li WANG
  • Received Date: 2014-09-28
  • Rev Recd Date: 2014-12-12
  • Publish Date: 2015-03-08
  • Gender and genetic strain are two prominent variants that influence drug abuse. Although certain sex-related behavioral responses have been previously characterized in ICR mice, little is known about the effects of sex on morphine-induced behavioral responses in this outbred strain. Therefore, in this study, we investigated the sex differences of morphine-induced locomotion, anxiety-like and social behaviors in ICR mice. After morphine or saline exposure for four consecutive days (twice daily), increased locomotion, more time spent in the central area, as well as attenuated rearing and self-grooming behaviors were found in morphine-treated females in an open field; no differences were found in locomotion and the time spent in the central area between male and female controls. When interacting with the same-sex individuals, female controls were engaged in more social investigation, following, body contacting and self-grooming behaviors than controls; morphine exposure reduced contacting and self-grooming behaviors in females; in contrast, these effects were not found in males. These results indicate that female ICR mice are more prosocial and are more susceptible to morphine exposure than males.
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