Volume 28 Issue 3
May  2007
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GAO Jia-li, LUO Yu-ping*, LI Si-guang. Molecular Evolution of miR-34 Gene Family. Zoological Research, 2007, 28(3): 271-278.
Citation: GAO Jia-li, LUO Yu-ping*, LI Si-guang. Molecular Evolution of miR-34 Gene Family. Zoological Research, 2007, 28(3): 271-278.

Molecular Evolution of miR-34 Gene Family

  • Received Date: 2006-12-18
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2007-06-22
  • miR-34 gene can regulate early development of mammalian. Using bioinformatics analysis of sequenced metazoan genomes, 54 miR-34 genes of 33 different animal species were found. Eighteen miR-34 genes were identified in the first time, suggesting miRNA are highly conservative and widespread in Eukaryotes. Of these mir-34 gene homologues identified in metazoan, 80% locate in the intergenic region, the others are in the intron or 3′UTR of protein-coding gene. miR-34 gene is conserved in various animals, and the mature sequences and precursors of mir-34 gene in metazoan analyzed share 68% and 38.89% sequence identity, respectively. However there is only a mir-34 gene in invertebrate and three mir-34 genes, mir-34a, mir-34b and mir-34c are present in almost all vertebrate. The phylogenetic analysis reveals that the miR-34 gene family of vertebrate originated from local and tandem duplications followed by mutation of individual base after divergence from invertebrate.
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