Volume 27 Issue 1
Jan.  2006
Turn off MathJax
Article Contents
YU Hua-lin , * YE Wen-rui MA Yi-liu WANG Ting-hua FENG Zhong-tang CHEN Ye. Correlation Between Dopamine D2 Receptor in the Orbital Frontal Cortex in Rat and the Processing of Morphine Dependence. Zoological Research, 2006, 27(1): 54-62.
Citation: YU Hua-lin , * YE Wen-rui MA Yi-liu WANG Ting-hua FENG Zhong-tang CHEN Ye. Correlation Between Dopamine D2 Receptor in the Orbital Frontal Cortex in Rat and the Processing of Morphine Dependence. Zoological Research, 2006, 27(1): 54-62.

Correlation Between Dopamine D2 Receptor in the Orbital Frontal Cortex in Rat and the Processing of Morphine Dependence

  • Received Date: 2005-04-07
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2006-02-22
  • With conditional place preference (CPP) of morphine dependent rats, the study focus on the effects of the DAD2 receptor in the orbital frontal cortex (OFC) in rat associated with the processing of opioid dependence. CPP models of morphine dependent rats were established by intraperintoneal injection and combined with environmental stimulation. Rats were devided into three groups received Quinpirole or Raclopride injection (agonist or antagonist of the DAD2 receptor) in OFC by a miniminjector after the last conditioning session and CPP was assessed by the time spent in the morphine-associated environment after conditioning. All dates were analysed by statistical method. The time in drug place of Raclopride intervene group showed respectively significantly longer than the control group in the 2nd withdrawal day (P<0.05), however the time of Quinpirole intervene group didn't show significant difference compared with control group (P>0.05). The results indicated that: (1) CPP models of morphine dependent rats were established successfully by intraperintoneal injection with the proper dosage with the reference of many related papers; (2) The DA system in OFC plays an important role in the procession of morphine dependence; (3) The damnification in orbital frontal cortex of animals who addicted in drugs will increase their drugs craving behavior. Clinically, it might indicate that we must cautiously operate intervention to the patients of drug addiction.
  • loading
  • Relative Articles

    [1] Bo ZHAN, Hong-Yuan MA, Jian-Li WANG, Chao-Bao LIU. Sex differences in morphine-induced behavioral sensitization and social behaviors in ICR mice. Zoological Research, 2015, 36(2): 103-108.
    [2] Jian-Li WANG, Bei WANG, Wen CHEN. Differences in cocaine-induced place preference persistence, locomotion and social behaviors between C57BL/6J and BALB/cJ mice. Zoological Research, 2014, 35(5): 426-435.  doi: 10.13918/j.issn.2095-8137.2014.5.426
    [3] Jian-Hong WANG. Non-human primate models in drug addiction deserve more attention. Zoological Research, 2014, 35(3): 172-173.  doi: 10.11813/j.issn.0254-5853.2014.3.172
    [4] Yao-Dong FAN, Hai-Chen NIU, Tanzeel Huma, Ling LI, Gui-Mei WANG, Li-Qi XU, He REN, Yuan-Ye MA, Hua-Lin YU. Blockage of glucocorticoid receptors during memory acquisition, retrieval and reconsolidation prevents the expression of morphine-induced conditioned place preferences in mice. Zoological Research, 2013, 34(E1): 5626-E.  doi: 10.3724/SP.J.1141.2013.E01E26
    [5] SUN Yong-Mei, YANG Jian-Zhen, SUN Hua-Ying, MA Yuan-Ye, WANG Jian-Hong. Establishment of tree shrew chronic morphine dependent model. Zoological Research, 2012, 33(1): 14-18.  doi: 10.3724/SP.J.1141.2012.01014
    [6] WU Xu-Jun, ZONG Wei, SUN Yong-Mei, HU Xin-Tian, MA Yuan-Ye, WANG Jian-Hong. Morphine addiction in non-human primates using rhesus monkeys. Zoological Research, 2012, 33(1): 89-91.  doi: 10.3724/SP.J.1141.2012.01089
    [7] LIU Xiao-Fen, YANG Guang, YANG Rui, JIA Qiang, GUAN Su-Dong. Effects of odor cue on morphine-induced dependence and craving in mice. Zoological Research, 2012, (2): 165-169.  doi: 10.3724/SP.J.1141.2012.02165
    [8] GU Chao-Yang, AN Shu-Cheng. Rat orbital frontal (orbital frontal cortex, OFC) GABA B receptor mechanisms in stress and depression. Zoological Research, 2011, 32(3): 329-336.  doi: 10.3724/SP.J.1141.2011.03329
    [9] MAO Yu, YANG Shang-Chuan, LIU Chang, MA Yuan-Ye, HU Xin-Tian. Effects of propranolol on acquisition and retrieval of morphine- induced conditioned place preference memories in ICR mice. Zoological Research, 2011, 32(6): 670-674.  doi: 10.3724/SP.J.1141.2011.06670
    [10] QI Ren-Li, QU Jia-Gui, CHEN Yan-Mei, MA Yuan-Ye, HU Xin-Tian. Differences in morphine-induced and food-induced conditioned place preference between adolescent and adult mice. Zoological Research, 2011, 32(5): 528-532.  doi: 10.3724/SP.J.1141.2011.05528
    [11] MENG Zhi-Qiang, ZHANG Yu-Hua, CHEN Nan-Hui, MIAO Ying-Da, HU Xin-Tian. Effects of Morphine on Pupil Light Reflex in Monkeys. Zoological Research, 2010, 31(3): 282-286.  doi: 10.3724/SP.J.1141.2010.03283
    [12] WU Kun, XU Lin, HUANG Jing-fei. Role of Specific Synaptic Plasticity Interfering Peptides in the Expression of Morphine Induced Conditioned Place Preference in Mice  . Zoological Research, 2009, 30(4): 389-395.  doi: 10.3724/SP.J.1141.2009.04389
    [13] LIU Xiao-fen, YAN Zi-li, WANG Jian-hong, HU Xin-tian, MA Yuan-ye. Effects of Withdrawal on Y-maze Spatial Recognition Memory in Mice after Long-term Morphine Injection. Zoological Research, 2009, 30(2): 199-203.  doi: 10.3724/SP.J.1141.2009.02199
    [14] NIU Hai-chen, LI Ling, SHANg Bin, SUN Ning-lei, GUAN Yi-liang, YU Hua-lin, Ma. Synergetic Inhibition of Bromocrptine and Baclofen on the Naloxone-induced Withdrawal Syndromes. Zoological Research, 2008, 29(6): 608-612.  doi: 10.3724/SP.J.1141.2008.06608
    [15] HE Jing, CHEN Yan-mei, WANG Jian-hong, MA Yuan-ye. Effect of Co-administration of Morphine and Cholinergic Antagonists on Y-maze Spatial Recognition Memory Retrieval and Locomotor Activity in Mice. Zoological Research, 2008, 29(6): 613-620.  doi: 10.3724/SP.J.1141.2008.06613
    [16] NIU Hai-chen, SHANG Bin, SUN Ning-lei, LI Ling, GUAN Yi-liang, YU Hua-lin, Ma Yuan. Baclofen Inhibited the Morphine-induced Conditioned Placed Preference and Withdrawal Syndromes. Zoological Research, 2008, 29(6): 621-626.  doi: 10.3724/SP.J.1141.2008.06621
    [17] FU Yu, CHEN Yan-mei, ZENG Tao, PENG Yan-ping, TIAN Shao-hua, MA Yu. Delta EEG Activity in Left Orbitofrontal Cortex in Rats Related to Food Reward and Craving. Zoological Research, 2008, 29(3): 260-264.  doi: 10.3724/SP.J.1141.2008.03260
    [18] YU Hua-lin, LIU Yan-cheng, FAN Yao-dong, MA Yi-liu, FENG Zhong-tang. Effect of Morphine on γ-band of EEG Activity in the Orbital Frontal Cortex of Rhesus Monkey. Zoological Research, 2005, 26(4): 442-445.
    [19] LI Yuan-You, LIN Hao-Ran. Effects of Dopamine,Estradiol and Testosterone on Gonadotropin Release From The Pituitary Fragments of Rana rugulosa. Zoological Research, 2000, 21(6): 441-445.
    [20] , , . Observations on Effect of Morphine and Diazepam on the Single unit Activity in Prefrontal Cortex of Conscious Rhesus Monkeys. Zoological Research, 1985, 6(3): 218-226.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2281) PDF downloads(1948) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return