Volume 20 Issue 4
Jul.  1999
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GUO Ren, CHEN Shu-fan, LUO Qi-sheng, WANG Qing-ling, YI Hong-kun, ZHAN Qiong-fen. Transgenic Mice as A Model For Neurovirulence Test of Live Poliomyelitis Vaccines. Zoological Research, 1999, 20(4): 241-246.
Citation: GUO Ren, CHEN Shu-fan, LUO Qi-sheng, WANG Qing-ling, YI Hong-kun, ZHAN Qiong-fen. Transgenic Mice as A Model For Neurovirulence Test of Live Poliomyelitis Vaccines. Zoological Research, 1999, 20(4): 241-246.

Transgenic Mice as A Model For Neurovirulence Test of Live Poliomyelitis Vaccines

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 1999-08-22
  • Transgenic mice carrying the human poliovirus receptor (PVRTg21) were inoculated intraspinally with 3 poliovirus vaccine type 3 (WHO/Ⅲ,93/363 and 3J) and 1 wild virus (Leon).The clinical data and pathological data indicated that Leon viruses were the most strong neurovirulent.Even a dose of 100 TCID[50] could make 100% of the Transgenic mice paralysis and death.When inoculated with 5.5 log[10] TCID[50] of the vaccine reference (WHO/Ⅲ),only 87.1% of the mice paralyzed and 51.7% of the mice died,and the other 2 lots of poliomyelitis vaccine (93/363 and 3J) were higher in the neurovirulence than the vaccine reference (WHO/Ⅲ).A good correlation was found between the monkey neurovirulence test (MNVT) and the PVRTg21 mouse neurovirulence test for the 3 vaccine lots.The experimental results showed that the PVRTg21 transgenic mice should possibly be an animal model for the neurovirulence evaluation of live poliomyelitis vaccines and epidemiological surveillance.
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