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ISSN 1878-7606 (Online)
CN 11-3745/N (Print)
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Specific function and modulation of teleost monocytes/macrophages: polarization and phagocytosis
Xin-Jiang Lu, Jiong Chen
Zoological Research    2019, 40 (3): 146-150.   DOI: 10.24272/j.issn.2095-8137.2019.035
Online available: 28 March 2019

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Macrophages exist in most tissues and play a variety of functions in vertebrates. Teleost fish species are found in most aquatic environments throughout the world and are quite diverse for a group of vertebrate animals. Due to whole genome duplication and environmental adaptation, teleost monocytes/macrophages possess a variety of different functions and modulations compared with those of mammals. A deeper understanding of teleost monocytes/macrophages in the immune system will not only help develop teleost-specific methods of disease prevention but will also help improve our understanding of the various immune mechanisms in mammals. In this review, we summarize the differences in polarization and phagocytosis of teleost and mammalian macrophages to improve our understanding of the various immune mechanisms in vertebrates.

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A transgenic monkey model for the study of human brain evolution
Lei Shi, Bing Su
Zoological Research    2019, 40 (3): 236-238.   DOI: 10.24272/j.issn.2095-8137.2019.031
Online available: 11 April 2019

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Why humans have large brains with higher cognitive abilities is a question long asked by scientists. However, much remains unknown, especially the underlying genetic mechanisms. With the use of a transgenic monkey model, we showed that human-specific sequence changes of a key brain development gene (primary microcephaly1, MCPH1) could result in detectable molecular and cognitive changes resembling human neoteny, a notable characteristic developed during human evolution.

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