,免疫活化,肠道完整性,微生物易位,SIVmac239,北平顶猴(Macaca leonine),中国猕猴(Macaca mulatta) ," /> ,免疫活化,肠道完整性,微生物易位,SIVmac239,北平顶猴(Macaca leonine),中国猕猴(Macaca mulatta) ,"/> Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (<em>Macaca leonina</em>)

Zoological Research ›› 2019, Vol. 40 ›› Issue (6): 522-531.doi: 10.24272/j.issn.2095-8137.2019.047

Special Issue: Animal models Immunology

• Articles • Previous Articles     Next Articles

Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina)

Ming-Xu Zhang1,2,Tian-Zhang Song1,2,Hong-Yi Zheng1,Xue-Hui Wang1,3,Ying Lu1,2,Han-Dan Zhang1,Ting Li1,Wei Pang1,Yong-Tang Zheng1,4()   

  1. 1. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, National Kunming High Level Biosafety Research Center for Non-human Primates, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China
    2. Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming Yunnan 650204, China
    3. School of Life Sciences, University of Science and Technology of China, Hefei Anhui 230026, China
    4. KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University, Suzhou Jiangsu 215123, China
  • Received:2018-12-13 Accepted:2019-03-07 Online:2019-11-18 Published:2019-10-14
  • Contact: Yong-Tang Zheng E-mail:zhengyt@mail.kiz.ac.cn
  • Supported by:
    This work was partly supported by grants from the National Natural Science Foundation of China(U1802284);13th Five-Year Key Scientific and Technological Program of China(2017ZX10304402-002-004);Knowledge Innovation Program of the Chinese Academy of Sciences(ZDRW-ZS-2016-4)

Abstract:

Microbial translocation is a cause of systemic immune activation in HIV/SIV infection. In the present study, we found a lower CD8+ T cell activation level in Macaca leonina (northern pig-tailed macaques, NPMs) than in Macaca mulatta (Chinese rhesus macaques, ChRMs) during SIVmac239 infection. Furthermore, the levels of plasma LPS-binding protein and soluble CD14 in NPMs were lower than those in ChRMs. Compared with ChRMs, SIV-infected NPMs had lower Chiu scores, representing relatively normal intestinal mucosa. In addition, no obvious damage to the ileum or colon epithelial barrier was observed in either infected or uninfected NPMs, which differed to that found in ChRMs. Furthermore, no significant microbial translocation (Escherichia coli) was detected in the colon or ileum of infected or uninfected NPMs, which again differed to that observed in ChRMs. In conclusion, NPMs retained superior intestinal integrity and limited microbial translocation during SIV infection, which may contribute to their lower immune activation compared with ChRMs.

Key words: Immune activation, Intestinal integrity, Microbial translocation, SIVmac239, Macaca leonina, Northern pig-tailed macaques, Macaca mulatta, Chinese rhesus macaques