ZHOU Chen*. 2010: Inhibition Effect of IL-1β on Calcium Channels Currents in Cultured Cortical Neurons of Rat. Zoological Research, 31(1): 89-93. DOI: 10.3724/SP.J.1141.2010.01089
Citation: ZHOU Chen*. 2010: Inhibition Effect of IL-1β on Calcium Channels Currents in Cultured Cortical Neurons of Rat. Zoological Research, 31(1): 89-93. DOI: 10.3724/SP.J.1141.2010.01089

Inhibition Effect of IL-1β on Calcium Channels Currents in Cultured Cortical Neurons of Rat

  • Interleukin-1β(IL-1β) is an important porinflammatory cytokine that exert wide biological functions in the central nervous system (CNS). Voltage-gated Ca2+ channels in plasma membrane are essential components of Ca2+ signal whose change on pathological conditions is closely related to processes of diseases. Although both IL-1βand Ca2+ channels have key roles in injury and disease of the brain, so far their relations have been reported in few studies. The effects of IL-1βon Ca2+ channels in cultured cortical neurons of rats were investigated using patch-clamp recording in present research. Our results showed that both 10 and 50 ng/mL of IL-1βtreatment inhibit the Ca2+ currents in time and dose dependent manner, without the change of activation properties of voltage-gated Ca2+ channels (VGCC)s.
  • loading

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return