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Zoological Research    2017, Vol. 38 Issue (6) : 317-320     DOI: 10.24272/j.issn.2095-8137.2017.075
Review |
Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum
Jie Zhang1, Guo-Hua Feng2, Chun-Yan Zou3, Pin-Can Su4, Huai-E Liu1,5, Zhao-Qing Yang1*
1 Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming Yunnan 650500, China;
2 Biomedical Engineering Research Center, Kunming Medical University, Kunming Yunnan 650500, China;
3 Guangxi Zhuang Autonomous Region People's Hospital, Nanning Guangxi 530021, China;
4 Transfusion Medicine Research Department, Yunnan Kunming Blood Center, Kunming Yunnan 650500, China;
5 Department of Infectious Diseases, The First Affiliated Hospital, Kunming Medical University, Kunming Yunnan 650032, China
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Abstract  Artemisinin resistance in Plasmodium falciparum threatens the remarkable efficacy of artemisinin-based combination therapies worldwide. Thus, greater insight into the resistance mechanism using monitoring tools is essential. The ring-stage survival assay is used for phenotyping artemisinin-resistance or decreased artemisinin sensitivity. Here, we review the progress of this measurement assay and explore its limitations and potential applications.
Keywords Malaria      Artemisinin      Resistant phenotype      Ring-stage survival assay      Improvement      Application     
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Fund:This study was funded by the National Natural Science Foundation of China (31260508, U1202226) and grants of Doctor Newcomer Scholarship from Yunnan province
Corresponding Authors: Zhao-Qing Yang,E-mail:zhaoqing92@hotmail.com   
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Jie Zhang, Guo-Hua Feng, Chun-Yan Zou, Pin-Can Su, Huai-E Liu, Zhao-Qing Yang. Overview of the improvement of the ring-stage survival assay-a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum. Zoological Research, 2017, 38(6): 317-320.
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http://www.zoores.ac.cn/EN/10.24272/j.issn.2095-8137.2017.075     OR     http://www.zoores.ac.cn/EN/Y2017/V38/I6/317
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