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ZOOLOGICAL RESEARCH    2011, Vol. 32 Issue (1) : 11-16     DOI: 10.3724/SP.J.1141.2011.01011
Articles |
Sero-epidemiology of six viruses natural infection in Tupaia belangeri chinensis
HAN Jian-Bao 1 , ZHANG Gao-Hong 1 , DUAN Yong 2, MA Jian-Ping 1, 4 , ZHANG Xi-He 1, 4 , LUO Rong-Hua 1 , LÜ Long-Bao 3 , ZHENG Yong-Tang 1,3 ,*
1. Key Laboratory of Animal Models and Human Diseases Mechanism of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming Yunnan 650223, China; 2. The First Affiliated Hospital of Kunming Medical College, Kunming Yunnan 650032, China; 3. Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming Yunnan 650223, China; 4. Graduate University of the Chinese Academy Sciences, Beijing 100049, China
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Abstract  
Tupaia (Tupaia belangeris chinensis, tree shrew) as a new experiment animal in medicine are non-rodent, small animals and close to primates in evolution. Experimental animals infected with viruses will affect the animal’s health, interference experiment, and even endanger the operator’s safety. Therefore, the viral infection in experimental animals has long been considered an important part of quality control. Lack of clearer viral natural infection information on the T. belangeris limits its use. Six viruses infection in 272 wild capture and artificial breeding Tupaia were investigated in this study. All serum samples were detected for the hepatitis B virus surface antigen, the total antibodies of HCV, hepatitis E virus (HEV), adenovirus (ADV), herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) by ELISA. The results showed that anti-HCV antibody and anti-HEV, ADV, HSV-1 IgG antibodies were negative, only one sample was positive of anti-HSV-2 IgG.. Three samples were positive in the primary ELISA detection of HBV surface antigen, but two pairs of semi-quantitative detection of hepatitis B and further recognized as negative. The results implied that antigen or antibody-positive results appeared in the hepatitis serological test is not accurate enough and confirmation by other virological indicators is necessary. Tupaia breeding herd should be screened for HSV-2 in order to prevent and control the virus infection.
Keywords Tree shrew      Tupaia      Natural infection      Virus      Serum      Epidemiology     
PACS:  Q95-33  
  R373  
  Q959.832  
Corresponding Authors: ZHENG Yong-Tang   
About author: HAN Jian-Bao(1978-)
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HAN Jian-Bao,ZHANG Gao-Hong,DUAN Yong,MA Jian-Ping,ZHANG Xi-He,LUO Rong-Hua,Lü. Sero-epidemiology of six viruses natural infection in Tupaia belangeri chinensis. ZOOLOGICAL RESEARCH, 2011, 32(1): 11-16.
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http://www.zoores.ac.cn/EN/10.3724/SP.J.1141.2011.01011     OR     http://www.zoores.ac.cn/EN/Y2011/V32/I1/11
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