Zoological Research ›› 2010, Vol. 31 ›› Issue (1): 57-65.doi: 10.3724/SP.J.1141.2010.01057

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Roles of Dendritic Cell in Disease Progression of AIDS Primate Models

XIA Hou-JUN 1,2 , ZHANG Gao-Hong 1 , ZHENG Yong-Tang 1,*   

  1. 1. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China; 2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
  • Received:2009-07-27 Revised:1900-01-01 Online:2010-02-22 Published:2010-02-22
  • Contact: ZHENG Yong-Tang

Abstract:

Non-human primate models are widely used in research of AIDS mechanism, transmission, vaccine and drugs. Dendritic cells (DC), as antigen presenting cells linking the innate immunity and acquired immunity, play a pivotal role in AIDS progression. Studies on the change of DC subsets number, phenotype and function in AIDS non-human primate models are important for revealing some mechanism of AIDS progression. This article reviews the progress in DC subsets of non-human primate AIDS models, which will provide an avenue for further study in AIDS.

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