Zoological Research ›› 2019, Vol. 40 ›› Issue (3): 211-218.doi: 10.24272/j.issn.2095-8137.2019.024

• Reports • Previous Articles     Next Articles

Passive eye movements induced by electromagnetic force (EMF) in rats

Yue Yu1, #, Jun Huang1, #, Chun-Ming Zhang2, Tian-Wen Chen1, David S. Sandlin3, Shao-Xun Wang1, 4, Alberto A. Arteaga1, Jerome Allison5, Yang Ou1, Susan Warren5, Paul May5, Hong Zhu1, 5,*, Wu Zhou1, 5, 6,*   

  1. 1. Departments of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson MS 39216, USA
    2. Department of Otolaryngology, First Affiliated Hospital, Shanxi Medical University, Taiyuan Shanxi 030001, China
    3. MD/PhD Program, University of Mississippi Medical Center, Jackson MS 39216, USA
    4. Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson MS 39216, USA
    5. Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson MS 39216, USA
    6. Neurology, University of Mississippi Medical Center, Jackson MS 39216, USA
  • Received:2018-07-18 Accepted:2018-10-18 Online:2019-05-18 Published:2019-04-19
  • Contact: Hong Zhu, Wu Zhou E-mail:wzhou@umc.edu; hozhu@umc.edu
  • Supported by:
    This study was supported by NIH grants to WZ (R21EY025550; R01DC014930) and HZ (R01DC012060)

Abstract: Accurate information on eye position in the orbit is available from visual feedback, efference copy of the oculomotor commands and proprioceptive signals from the extraocular muscles (EOM). Whereas visual feedback and oculomotor commands have been extensively studied, central processing of EOM proprioceptive signals remains to be elucidated. A challenge to the field is to develop an approach to induce passive eye movements without physically contacting the eyes. A novel method was developed to generate passive eye movements in rats. A small rare-earth magnet disk (0.7 mm diameter, 0.5 mm thickness) was attached to the surface of a rat’s eyeball. A metal rod (5 mm diameter) wrapped with an electromagnetic (EM) coil was placed near the magnet (8–15 mm). By passing currents to the EM coil, electromagnetic force (EMF) was generated and acted upon the magnet and induced passive eye movements. The EMF induced well-defined passive eye movements, whose directions were dependent on current polarity and amplitudes and peak velocities were dependent on current intensity and duration. Peak velocities of the EMF-induced eye movements were linearly related to amplitudes, exhibiting main sequence relationships similar to that of saccades in awake rats and eye movements induced by electrical microstimulation of the abducens nucleus in anesthetized rats. Histological examination showed that repetitive EMF stimulations did not appear to result in damages in the EOM fibers. These results validated the EMF approach as a novel tool to investigate EOM proprioceptive signals and their roles in visual localization and gaze control.

Key words: Eye movement, Proprioception, Extraocular muscles, Stretch reflex

No related articles found!
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] LIU Wei-bin,GONG Cheng-liang,XUE Ren-yu,ZHOU Wen-lin,ZHU Xu-xian,CAO Guang-li *. Cloning and Analysis of Fhx/P25 Gene Promoter of Bombyx mori Fibroin Protein[J]. Zoological Research, 2007, 28(1): 17 -23 .
[2] ZHANG Shu-chao,YUE Bi-song,ZOU Fang-dong*. Isolation and Characterization of Microsatellite DNA Markers from Forest Musk Deer (Moschus berezovskii)(in English)[J]. Zoological Research, 2007, 28(1): 24 -27 .
[3] PAN Pu-liang,WANG Hong,N.G.Jablonski. Long Bone and Skeletal Allometry in Rhinopithecus[J]. Zoological Research, 1989, 10(1): 23 -30 .
[4] HOU Yi-di,PENG Yan-zhang. A Description of New Species of Trichocephalus (Trichocephalidae,Trichocephalata) From The Golden Monkey,Rhinopithecus Bieti[J]. Zoological Research, 1989, 10(1): 45 -50 .
[5] CHEN Yi,TANG Jue. Studies on Colony structure and Life Cycle of The Spined ant,Polyrhchis Vicina Roger[J]. Zoological Research, 1989, 10(1): 57 -63 .
[6] LI Fan,ZHONG Jun-sheng. A NEW SPECIES OF RHINOGOBIUS FROM ZHEJIANG PROVINCE, CHINA (Teleostei: Gobiidae)[J]. Zoological Research, 2007, 28(5): 539 -544 .
[7] TANGSu-ni,HUANG Jing-fei. Evolutionary Diversities of Aminoacyl-tRNA Synthetases[J]. Zoological Research, 2007, 28(5): 563 -567 .
[8] . New Proof for Astrocytes Having L-type Calcium Channels[J]. Zoological Research, 2007, 28(5): 485 -490 .
[9] MA Dong-mei,ZHU Hua-ping,GUI Jian-fang. Molecular Cloning and Expression Characterization of Prox1 in Goldfish (Carassius auratus) Eye Development[J]. Zoological Research, 2007, 28(6): 589 -596 .
[10] DING Fang,ZHOU Hong-lin,LIU Yang,MA Lan,SU Ying,DU Ling. Effects of Glucose on Development of ICR Mouse Embryosin vitro[J]. Zoological Research, 2007, 28(5): 501 -506 .