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Zoological Research    2018, Vol. 39 Issue (2) : 72-86     DOI: 10.24272/j.issn.2095-8137.2017.055
Reviews |
Kidney disease models: tools to identify mechanisms and potential therapeutic targets
Yin-Wu Bao1,2, Yuan Yuan1,2, Jiang-Hua Chen1, Wei-Qiang Lin1,2,*
1 Kidney Disease Center, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou Zhejiang 310058, China 
2 Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou Zhejiang 310058, China
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Abstract  Acute kidney injury (AKI) and chronic kidney disease (CKD) are worldwide public health problems affecting millions of people and have rapidly increased in prevalence in recent years. Due to the multiple causes of renal failure, many animal models have been developed to advance our understanding of human nephropathy. Among these experimental models, rodents have been extensively used to enable mechanistic understanding of kidney disease induction and progression, as well as to identify potential targets for therapy. In this review, we discuss AKI models induced by surgical operation and drugs or toxins, as well as a variety of CKD models (mainly genetically modified mouse models). Results from recent and ongoing clinical trials and conceptual advances derived from animal models are also explored.
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Fund:This study was supported by the General Program of the National Natural Science Foundation of China (51309220, 31470776) and QianJiang Talent Plan to W.Q. Lin
Corresponding Authors: Wei-Qiang Lin,E-mail: wlin@zju.edu.cn   
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Yin-Wu Bao, Yuan Yuan, Jiang-Hua Chen, Wei-Qiang Lin. Kidney disease models: tools to identify mechanisms and potential therapeutic targets. Zoological Research, 2018, 39(2): 72-86.
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http://www.zoores.ac.cn/EN/10.24272/j.issn.2095-8137.2017.055     OR     http://www.zoores.ac.cn/EN/Y2018/V39/I2/72
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