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Zoological Research    2018, Vol. 39 Issue (1) : 15-24     DOI: 10.24272/j.issn.2095-8137.2017.053
Reviews |
Animal models for filovirus infections
Vinayakumar Siragam1,2, Gary Wong1,2,3,4, Xiang-Guo Qiu1,2,*
1 Special Pathogens Program, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
2 Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada
3 Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People’s Hospital, Shenzhen Guangzhou 518020, China
4 Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
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Abstract  The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.
Keywords Filovirus      Ebola virus      Marburg virus      Marburg virus disease      Ebola virus disease      Mouse-adapted ebolavirus      Guinea-pig-adapted ebolavirus      Sudan virus      Plaque-forming units     
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Fund:This work was supported by the Public Health Agency of Canada (PHAC), partially supported by the NIH and CIHR grants to X. G. Qiu (U19 AI109762-1 and CIHR-IER-143487, respectively), and grants from the National Natural Science Foundation of China International Cooperation and Exchange Program (8161101193) and National Science and Technology Major Project (2016ZX10004222) to G. Wong
Corresponding Authors: Xiang-Guo Qiu,E-mail:xiangguo.qiu@phac-aspc.gc.ca   
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Vinayakumar Siragam, Gary Wong, Xiang-Guo Qiu. Animal models for filovirus infections. Zoological Research, 2018, 39(1): 15-24.
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http://www.zoores.ac.cn/EN/10.24272/j.issn.2095-8137.2017.053     OR     http://www.zoores.ac.cn/EN/Y2018/V39/I1/15
[1] Gary Wong, Xiang-Guo Qiu. Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential[J]. Zoological Research, 2018, 39(1): 3-14.
[2] Gary Wong, Wen-Guang Cao, Shi-Hua He, Zi-Rui Zhang, Wen-Jun Zhu, Estella Moffat, Hideki Ebihara, Carissa Embury-Hyatt, Xiang-Guo Qiu. Development and characterization of a guinea pig model for Marburg virus[J]. Zoological Research, 2018, 39(1): 32-41.
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