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Zoological Research    2018, Vol. 39 Issue (1) : 3-14     DOI: 10.24272/j.issn.2095-8137.2017.052
Reviews |
Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential
Gary Wong1,2,3,4,*, Xiang-Guo Qiu3,4
1 Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People’s Hospital, Shenzhen Guangzhou 518020,  China
2 Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
3 Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
4 Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada
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Abstract  Due to their inability to generate a complete immune response, mice knockout for type I interferon (IFN) receptors (Ifnar–/–) are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to study many diseases caused by highly pathogenic viruses from many families, including the Flaviviridae, Filoviridae, Arenaviridae, Bunyaviridae, Henipaviridae, and Togaviridae. In this review, we summarize the findings from these animal studies, and discuss the pros and cons of using this model versus other known methods for studying pathogenesis in animals.
Keywords Ifnar      Mice      Animal model      Flavivirus      Filovirus      Arenavirus      Bunyavirus      Henipavirus      Togavirus     
Fund:This study was supported by the National Natural Science Foundation of China International Cooperation and Exchange Program (8161101193) and the National Science and Technology Major Project (2016ZX10004222) to G. Wong
Corresponding Authors: Gary Wong,   
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Gary Wong, Xiang-Guo Qiu. Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential. Zoological Research, 2018, 39(1): 3-14.
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