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ZOOLOGICAL RESEARCH    2014, Vol. 35 Issue (6) : 485-491     DOI: 10.13918/j.issn.2095-8137.2014.6.485
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Experimental infection of tree shrews(Tupaia belangeri) with Coxsackie virus A16
Jian-Ping LI, Yun LIAO, Ying ZHANG, Jing-Jing WANG, Li-Chun WANG, Kai FENG, Qi-Han LI, Long-Ding LIU
Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical Colleg, Kunming 650118, China
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Abstract  

Coxsackie virus A16 (CA16) is commonly recognized as one of the main human pathogens of hand-foot-mouth disease (HFMD). The clinical manifestations of HFMD include vesicles of hand, foot and mouth in young children and severe inflammatory CNS lesions. In this study, experimentally CA16 infected tree shrews(Tupaia belangeri) were used to investigate CA16 pathogenesis. The results showed that both the body temperature and the percentages of blood neutrophilic granulocytes / monocytes of CA16 infected tree shrews increased at 4-7 days post infection. Dynamic distributions of CA16 in different tissues and stools were found at different infection stages. Moreover, the pathological changes in CNS and other organs were also observed. These findings indicate that tree shrews can be used as a viable animal model to study CA16 infection.

Keywords Coxsackie virus A16      Infection      Tree shrew     
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This work was supported by the National High-Tech R&D Program (2014ZX09102042), the National Natural Science Foundation of China (81373142) and the Natural Science Foundation of Yunnan Province (2012ZA009)

Corresponding Authors: Qi-Han LI, Long-Ding LIU   
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Jian-Ping LI
Yun LIAO
Ying ZHANG
Jing-Jing WANG
Li-Chun WANG
Kai FENG
Qi-Han LI
Long-Ding LIU
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Jian-Ping LI,Yun LIAO,Ying ZHANG, et al. Experimental infection of tree shrews(Tupaia belangeri) with Coxsackie virus A16[J]. ZOOLOGICAL RESEARCH, 2014, 35(6): 485-491.
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http://www.zoores.ac.cn/EN/10.13918/j.issn.2095-8137.2014.6.485     OR     http://www.zoores.ac.cn/EN/Y2014/V35/I6/485
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