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马迅, 黄芯渝, 谭晞彦, 崔雍建, 钟礼瞬, 冯波. 2018: 多样化CRISPR技术在动物体内基因编辑研究中的应用和进展. 动物学研究, 39(2): 58-71. DOI: 10.24272/j.issn.2095-8137.2017.012
引用本文: 马迅, 黄芯渝, 谭晞彦, 崔雍建, 钟礼瞬, 冯波. 2018: 多样化CRISPR技术在动物体内基因编辑研究中的应用和进展. 动物学研究, 39(2): 58-71. DOI: 10.24272/j.issn.2095-8137.2017.012
Xun Ma, Avery Sum-Yu Wong, Hei-Yin Tam, Samuel Yung-Kin Tsui, Dittman Lai-Shun Chung, Bo Feng. 2018: In vivo genome editing thrives with diversified CRISPR technologies. Zoological Research, 39(2): 58-71. DOI: 10.24272/j.issn.2095-8137.2017.012
Citation: Xun Ma, Avery Sum-Yu Wong, Hei-Yin Tam, Samuel Yung-Kin Tsui, Dittman Lai-Shun Chung, Bo Feng. 2018: In vivo genome editing thrives with diversified CRISPR technologies. Zoological Research, 39(2): 58-71. DOI: 10.24272/j.issn.2095-8137.2017.012

多样化CRISPR技术在动物体内基因编辑研究中的应用和进展

In vivo genome editing thrives with diversified CRISPR technologies

  • 摘要: CRISPR/Cas 系统是细菌和古生菌中抵抗外源病毒或质粒入侵的获得性免疫系统。近期科学研究通过分子生物学改造将其发展成为了一种简洁高效的靶向基因组编辑工具,其颠覆性效果在各种研究体系中得到了广泛的证实,展现了前所未有的应用前景。随着相关研究的深入发展,各种DNA修复机制在CRISPR/Cas诱导的定点断裂的修复过程中所发挥的作用,被进一步关注,并被发掘使用于进一步拓宽基因组编辑的操作范围和种类。多样化的CRISPR技术为动物模型的构建提供了更加快捷、高效平台,使得过去难以实施的复杂的靶向基因编辑在更多的动物模型中得以实现。本文就近年来CRISPR技术在动物研究的发展和应用进行回顾和总结,深入探讨了相关研究进展在生物医学领域的广泛影响。

     

    Abstract: Prokaryotic type II adaptive immune systems have been developed into the versatile CRISPR technology, which has been widely applied in site-specific genome editing and has revolutionized biomedical research due to its superior efficiency and flexibility. Recent studies have greatly diversified CRISPR technologies by coupling it with various DNA repair mechanisms and targeting strategies. These new advances have significantly expanded the generation of genetically modified animal models, either by including species in which targeted genetic modification could not be achieved previously, or through introducing complex genetic modifications that take multiple steps and cost years to achieve using traditional methods. Herein, we review the recent developments and applications of CRISPR-based technology in generating various animal models, and discuss the everlasting impact of this new progress on biomedical research.

     

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